Epha7 Eph receptor A7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha7provided by MGI
Official Full Name: Eph receptor A7provided by MGI
Primary source: MGI:MGI:95276
See related: Ensembl:ENSMUSG00000028289 AllianceGenome:MGI:95276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ebk; Ehk3; Mdk1; Cek11; Hek11
Summary: Enables chemorepellent activity; growth factor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of nervous system development; and regulation of protein phosphorylation. Acts upstream of or within nephric duct morphogenesis; nervous system development; and positive regulation of neuron apoptotic process. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; foot bone; genitourinary system; and sensory organ. Orthologous to human EPHA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 6.7), CNS E11.5 (RPKM 6.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A4; 4 12.42 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (28811840..28969391)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (28813066..28967503)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of EphA7 in different tumors.
Title: The role of EphA7 in different tumors.
Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
Title: Satb2 Regulates EphA7 to Control Soma Spacing and Self-Avoidance of Cortical Pyramidal Neurons.
Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
Title: Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis.
EphA7 promotes myogenic differentiation via cell-cell contact.
Title: EphA7 promotes myogenic differentiation via cell-cell contact.
Data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation by which BMI-1 controls cell proliferation in the postnatal lateral ventricle wall.
Title: The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
The present study demonstrates that EphA7 receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
Title: EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.
Results suggest that EphA7 plays an important role in the developmental formation of cochlear innervation pattern through controlling spiral ganglion neuron fiber ontogeny
Title: EphA7 regulates spiral ganglion innervation of cochlear hair cells.
Truncated EPHA7 promotes cell reprogramming by inducing ERK activity reduction.
Title: Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction.
Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model.
Title: Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model.
Results support the hypothesis that the anatomical organization of striatal and thalamic neurons expressing EphA7 receptors restricts the topographic distribution of cortical afferents from medial regions of S1 which express high levels of ephrin-A5
Title: Corticofugal projections from medial primary somatosensory cortex avoid EphA7-expressing neurons in striatum and thalamus.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epha7 (e-PCR), detects polymorphism
- UniSTS:495885

NoName (e-PCR)
- UniSTS:224532

UniSTS:224539 (e-PCR)
- UniSTS:224539

NoName (e-PCR)
- UniSTS:224549

Epha7 (e-PCR), detects polymorphism
- UniSTS:226135

NoName (e-PCR)
- UniSTS:548484

NoName (e-PCR)
- UniSTS:548485

Epha7 (e-PCR), detects polymorphism
- UniSTS:531334

Epha7 (e-PCR), detects polymorphism
- UniSTS:545931

UniSTS:266990 (e-PCR)
- UniSTS:266990

Epha7 (e-PCR), detects polymorphism
- UniSTS:266990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables axon guidance receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chemorepellent activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of a nerve	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nephric duct morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-A receptor 7

Names: EPH homology kinase 3; developmental kinase 1; embryonic brain kinase

NP_001116361.1

EC 2.7.10.1

NP_001277363.1

EC 2.7.10.1

NP_001407841.1

EC 2.7.10.1

NP_001407842.1

EC 2.7.10.1

NP_001407843.1

EC 2.7.10.1

NP_034271.3

EC 2.7.10.1

XP_006537670.1

EC 2.7.10.1

XP_036019542.1

EC 2.7.10.1

XP_036019543.1

EC 2.7.10.1

XP_036019544.1

EC 2.7.10.1

XP_036019545.1

EC 2.7.10.1

XP_036019547.1

EC 2.7.10.1

XP_036019548.1

EC 2.7.10.1

XP_036019549.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122889.2 → NP_001116361.1 ephrin type-A receptor 7 isoform 2 precursor

See identical proteins and their annotated locations for NP_001116361.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

BX000989

Consensus CDS

CCDS51132.1

UniProtKB/TrEMBL

Q8CC52

Related

ENSMUSP00000079735.5, ENSMUST00000080934.11

Conserved Domains (4) summary

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:333 → 427

fn3; Fibronectin type III domain

pfam07699
Location:275 → 312

GCC2_GCC3; GCC2 and GCC3
NM_001290434.2 → NP_001277363.1 ephrin type-A receptor 7 isoform 3 precursor

See identical proteins and their annotated locations for NP_001277363.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

BX000989

Consensus CDS

CCDS71353.1

UniProtKB/TrEMBL

A2BDQ4, Q8R381

Related

ENSMUSP00000103826.2, ENSMUST00000108191.2

Conserved Domains (7) summary

cd09548
Location:915 → 984

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

smart00454
Location:916 → 983

SAM; Sterile alpha motif

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:624 → 890

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:629 → 886

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:565 → 624

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_001420912.1 → NP_001407841.1 ephrin type-A receptor 7 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

BX000989
NM_001420913.1 → NP_001407842.1 ephrin type-A receptor 7 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

BX000989
NM_001420914.1 → NP_001407843.1 ephrin type-A receptor 7 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

BX000989
NM_010141.5 → NP_034271.3 ephrin type-A receptor 7 isoform 1 precursor

See identical proteins and their annotated locations for NP_034271.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BX000989

Consensus CDS

CCDS18013.1

UniProtKB/Swiss-Prot

Q61505, Q61772, Q61773, Q61774, Q8BSU8

UniProtKB/TrEMBL

Q8R381

Related

ENSMUSP00000029964.6, ENSMUST00000029964.12

Conserved Domains (7) summary

cd09548
Location:919 → 988

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

smart00454
Location:920 → 987

SAM; Sterile alpha motif

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:628 → 894

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:633 → 890

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:565 → 628

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

28811840..28969391

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537607.5 → XP_006537670.1 ephrin type-A receptor 7 isoform X9

See identical proteins and their annotated locations for XP_006537670.1

UniProtKB/Swiss-Prot

Q61772

Related

ENSMUSP00000103829.3, ENSMUST00000108194.9

Conserved Domains (3) summary

cd10485
Location:30 → 206

EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7

cd00063
Location:443 → 534

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07699
Location:275 → 312

Ephrin_rec_like; Putative ephrin-receptor like
XM_036163651.1 → XP_036019544.1 ephrin type-A receptor 7 isoform X3

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:838 → 907

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:547 → 813

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:484 → 549

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163652.1 → XP_036019545.1 ephrin type-A receptor 7 isoform X4

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:834 → 903

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:543 → 809

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:484 → 545

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163649.1 → XP_036019542.1 ephrin type-A receptor 7 isoform X1

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:843 → 912

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:552 → 818

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:489 → 554

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163650.1 → XP_036019543.1 ephrin type-A receptor 7 isoform X2

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:839 → 908

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:548 → 814

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:489 → 550

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163656.1 → XP_036019549.1 ephrin type-A receptor 7 isoform X7

Conserved Domains (4) summary

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:257 → 351

fn3; Fibronectin type III domain

pfam07699
Location:199 → 236

Ephrin_rec_like; Putative ephrin-receptor like

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163654.1 → XP_036019547.1 ephrin type-A receptor 7 isoform X1

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:843 → 912

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:552 → 818

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:489 → 554

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_036163655.1 → XP_036019548.1 ephrin type-A receptor 7 isoform X1

UniProtKB/TrEMBL

Q8R381

Conserved Domains (5) summary

cd09548
Location:843 → 912

SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors

cd00063
Location:367 → 458

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:552 → 818

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:489 → 554

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 130

EphR_LBD; Ligand Binding Domain of Ephrin Receptors