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    Mlf1 myeloid leukemia factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17349, updated on 8-Jul-2021

    Summary

    Official Symbol
    Mlf1provided by MGI
    Official Full Name
    myeloid leukemia factor 1provided by MGI
    Primary source
    MGI:MGI:1341819
    See related
    Ensembl:ENSMUSG00000048416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HL; HLS7
    Expression
    Biased expression in testis adult (RPKM 137.0) and heart adult (RPKM 22.3) See more
    Orthologs
    NEW
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    Genomic context

    See Mlf1 in Genome Data Viewer
    Location:
    3 E1; 3 30.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67281430..67307333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67374097..67400000)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (67178019..67203922)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568616 Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 22295 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene latexin Neighboring gene predicted gene, 40067

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myeloid progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myeloid leukemia factor 1
    Names
    hematopoietic lineage switch 7
    myelodysplasia-myeloid leukemia factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039543.2NP_001034632.1  myeloid leukemia factor 1 isoform a

      See identical proteins and their annotated locations for NP_001034632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK133448, BC027526
      Consensus CDS
      CCDS17395.1
      UniProtKB/TrEMBL
      Q3V042, Q8JZS2
      Related
      ENSMUSP00000058596.9, ENSMUST00000061322.10
      Conserved Domains (1) summary
      pfam10248
      Location:27217
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
    2. NM_010801.3NP_034931.2  myeloid leukemia factor 1 isoform b

      See identical proteins and their annotated locations for NP_034931.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK133448, BC027526
      Consensus CDS
      CCDS17396.1
      UniProtKB/Swiss-Prot
      Q9QWV4
      UniProtKB/TrEMBL
      Q3V042, Q8JZS2
      Related
      ENSMUSP00000077072.6, ENSMUST00000077916.12
      Conserved Domains (1) summary
      pfam10248
      Location:27202
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      67281430..67307333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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