Fgfbp1 fibroblast growth factor binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgfbp1provided by MGI
Official Full Name: fibroblast growth factor binding protein 1provided by MGI
Primary source: MGI:MGI:1096350
See related: Ensembl:ENSMUSG00000048373 AllianceGenome:MGI:1096350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FGF-BP; FGF-BP1; FGFBP-1
Summary: Enables fibroblast growth factor binding activity. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of fibroblast growth factor receptor signaling pathway. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; meninges; and skin. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 24.0), stomach adult (RPKM 14.7) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 23.95 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (44136200..44139173, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (43978858..43981828, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting FAPalpha-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
Title: Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.
Title: Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.
Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1).
Title: Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1).
Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/beta-catenin signaling.
Title: Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
Study using Fgfbp1-knockout mice concludes that tissue-resident and circulating Fgfbp1-expressing cells modulate skin carcinogenesis and inflammation.
Title: The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.
FGFBP1 expression decreases in skeletal muscles during aging and before neuromuscular junctions degeneration in SOD1(G93A) mice
Title: Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS.
From the locally confined, time-dependent, and apparently tightly regulated FGF-BP expression, it is proposed that FGF-BP may play an important role in embryonic development.
Title: Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development.
The upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.
Title: Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.
the FGF interaction domain is contained in the C terminus of FGF-BP1
Title: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgfbp1 (e-PCR), detects polymorphism
- UniSTS:545934

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myoblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor-binding protein 1

Names: FGF-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271616.1 → NP_001258545.1 fibroblast growth factor-binding protein 1 precursor

See identical proteins and their annotated locations for NP_001258545.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC164004, BC065774, CB524251, DV059653

Consensus CDS

CCDS19268.1

UniProtKB/Swiss-Prot

O70514, Q62399

Related

ENSMUSP00000142520.2, ENSMUST00000199894.2

Conserved Domains (1) summary

pfam06473
Location:15 → 247

FGF-BP1; FGF binding protein 1 (FGF-BP1)
NM_001421576.1 → NP_001408505.1 fibroblast growth factor-binding protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC164004

UniProtKB/Swiss-Prot

O70514, Q62399
NM_001421577.1 → NP_001408506.1 fibroblast growth factor-binding protein 1 precursor

Status: VALIDATED

Source sequence(s)

AC164004

UniProtKB/Swiss-Prot

O70514, Q62399
NM_008009.4 → NP_032035.2 fibroblast growth factor-binding protein 1 precursor

See identical proteins and their annotated locations for NP_032035.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC164004, BC065774, CB524251

Consensus CDS

CCDS19268.1

UniProtKB/Swiss-Prot

O70514, Q62399

Related

ENSMUSP00000056900.8, ENSMUST00000061299.9

Conserved Domains (1) summary

pfam06473
Location:15 → 247

FGF-BP1; FGF binding protein 1 (FGF-BP1)