Bop1 block of proliferation 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bop1provided by MGI
Official Full Name: block of proliferation 1provided by MGI
Primary source: MGI:MGI:1334460
See related: Ensembl:ENSMUSG00000022557 AllianceGenome:MGI:1334460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erb1p; Kiaa0124; mKIAA0124
Summary: Enables ribonucleoprotein complex binding activity. Involved in cell population proliferation and cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within rRNA processing and ribosomal large subunit biogenesis. Located in nucleolus. Is expressed in several structures, including female reproductive system and urinary system. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 54.9), thymus adult (RPKM 50.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.91 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76337188..76361449, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76452988..76477249, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
Title: BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
PDGF-C promotes cell proliferation partially via downregulating BOP1.
Title: PDGF-C promotes cell proliferation partially via downregulating BOP1.
BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
Title: BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
BOP1 knockdown promoted down-regulation of the MAPK phosphatases DUSP4 and DUSP6 via a transcription-based mechanism, leading to increased MAPK signaling.
Title: Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway.
New direct Wnt/beta-catenin target gene Bop1, which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified.
Title: New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Murine fibroblasts expressing Scx mRNA from an exogenous Scx mini-gene indicated that the accumulation of Bop1 intronic RNA impairs the Scx gene expression in a trans-acting manner, which resulted in the reduction of the Scx mRNA level.
Title: Estrogen down-regulation of the Scx gene is mediated by the opposing strand-overlapping gene Bop1.
inactivation of inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression
Title: Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression.
Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex).
Title: Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.
Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association.
Title: Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237330

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH136369 (e-PCR)
- UniSTS:210359

AW146150 (e-PCR)
- UniSTS:160465

Scx (e-PCR), detects polymorphism
- UniSTS:233954

AI169617 (e-PCR)
- UniSTS:250361

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PeBoW complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ribosome biogenesis protein BOP1

Names: block of proliferation 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013481.2 → NP_038509.1 ribosome biogenesis protein BOP1

See identical proteins and their annotated locations for NP_038509.1

Status: VALIDATED

Source sequence(s)

AK079627, AV349722

Consensus CDS

CCDS27570.1

UniProtKB/Swiss-Prot

P97452, Q3TK87, Q6ZQI9, Q91X31

UniProtKB/TrEMBL

Q3TJZ5

Related

ENSMUSP00000023217.10, ENSMUST00000023217.11

Conserved Domains (4) summary

COG2319
Location:395 → 732

WD40; WD40 repeat [General function prediction only]

cd00200
Location:394 → 732

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08145
Location:130 → 388

BOP1NT; BOP1NT (NUC169) domain

sd00039
Location:403 → 441

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

76337188..76361449 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159096.1 → XP_036014989.1 ribosome biogenesis protein BOP1 isoform X1

Conserved Domains (3) summary

cd00200
Location:233 → 571

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:242 → 280

7WD40; WD40 repeat [structural motif]

pfam08145
Location:1 → 227

BOP1NT; BOP1NT (NUC169) domain