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    Mtfmt mitochondrial methionyl-tRNA formyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 69606, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mtfmtprovided by MGI
    Official Full Name
    mitochondrial methionyl-tRNA formyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1916856
    See related
    Ensembl:ENSMUSG00000059183 AllianceGenome:MGI:1916856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310020P08Rik
    Summary
    Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.3), CNS E14 (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 C; 9 35.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65343064..65360336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65435782..65453054)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 13 Neighboring gene RAS-like, family 12 Neighboring gene solute carrier family 51, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E6755 Neighboring gene STARR-positive B cell enhancer ABC_E2295 Neighboring gene STARR-positive B cell enhancer ABC_E2895 Neighboring gene SPG21, maspardin Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_24454 Neighboring gene predicted gene, 17749

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes. Arguello T, et al. J Biol Chem, 2018 Sep 28. PMID 30087118, Free PMC Article
    2. Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site. Arguello T, et al. Genesis, 2015 Nov. PMID 26331883, Free PMC Article
    3. Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice. Sun X, et al. Int J Mol Sci, 2023 Mar 22. PMID 36983072, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.
      Title: Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.
    2. Here, we generated a Mtfmt-KO mouse fibroblast cell line and demonstrated that N-formylation of the first methionine via fMet-tRNA(Met) by MTFMT is not an absolute requirement for initiation of protein synthesis.
      Title: Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methionyl-tRNA formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionyl-tRNA formyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methionyl-tRNA formyltransferase, mitochondrial
    NP_081410.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027134.3 → NP_081410.2  methionyl-tRNA formyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_081410.2

      Status: VALIDATED

      Source sequence(s)
      AK009430, AK133492
      Consensus CDS
      CCDS23292.1
      UniProtKB/Swiss-Prot
      E9QKZ0, Q8VE89, Q9D799
      UniProtKB/TrEMBL
      Q3V021
      Related
      ENSMUSP00000074347.7, ENSMUST00000074792.7
      Conserved Domains (3) summary
      cd08646
      Location:43 → 239
      FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
      TIGR00460
      Location:31 → 353
      fmt; methionyl-tRNA formyltransferase
      cl14785
      Location:243 → 343
      FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65343064..65360336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D799.3 GenPept UniProtKB/Swiss-Prot:Q9D799

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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