Sdr9c7 4short chain dehydrogenase/reductase family 9C, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdr9c7provided by MGI
Official Full Name: 4short chain dehydrogenase/reductase family 9C, member 7provided by MGI
Primary source: MGI:MGI:1917311
See related: Ensembl:ENSMUSG00000040127 AllianceGenome:MGI:1917311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rdhs; Sdro; Rdh20; SDR-O; 1810054F20Rik
Summary: Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be located in cytoplasm. Is expressed in embryo and liver. Used to study autosomal recessive congenital ichthyosis 13. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13. Orthologous to human SDR9C7 (short chain dehydrogenase/reductase family 9C member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 5.3), stomach adult (RPKM 2.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127734404..127747630)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127898535..127911761)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.
Title: SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.
short-chain dehydrogenase/reductase (SDR), retinol dehydrogenase-similar (RDH-S), with intense mRNA expression in liver and kidney
Title: Identification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: short-chain dehydrogenase/reductase family 9C member 7

Names: RDH-S; orphan short chain dehydrogenase/reductase; retinol dehydrogenase 20

NP_081577.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027301.3 → NP_081577.1 short-chain dehydrogenase/reductase family 9C member 7

See identical proteins and their annotated locations for NP_081577.1

Status: VALIDATED

Source sequence(s)

BC064820

Consensus CDS

CCDS24256.1

UniProtKB/Swiss-Prot

Q8K3P0

Related

ENSMUSP00000036628.8, ENSMUST00000047134.8

Conserved Domains (2) summary

cd09805
Location:26 → 302

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:26 → 207

adh_short; short chain dehydrogenase