U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68119, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cmtm3provided by MGI
    Official Full Name
    CKLF-like MARVEL transmembrane domain containing 3provided by MGI
    Primary source
    MGI:MGI:2447162
    See related
    Ensembl:ENSMUSG00000031875 AllianceGenome:MGI:2447162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BNAS2; Cklfsf3; 9430096L06Rik
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within blastocyst hatching and positive regulation of B cell receptor signaling pathway. Located in cytoplasm and nuclear membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human CMTM3 (CKLF like MARVEL transmembrane domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 59.8), adrenal adult (RPKM 43.1) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105065993..105074304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104339383..104347672)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45710 Neighboring gene CKLF-like MARVEL transmembrane domain containing 2B Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene STARR-positive B cell enhancer ABC_E11745

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling. Ye J, et al. Biochem Biophys Res Commun, 2023 Jul 30. PMID 37229825
    2. In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ). Wang J, et al. Cell Oncol (Dordr), 2023 Feb. PMID 36284038
    3. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. Imamura Y, et al. J Biol Chem, 2004 Jun 18. PMID 15087455
    4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Han W, et al. Genomics, 2003 Jun. PMID 12782130
    5. The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Wilm B, et al. Dev Biol, 2004 Jul 1. PMID 15196959

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling.
      Title: CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling.
    2. In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARgamma).
      Title: In vivo study revealed pro-tumorigenic effect of CMTM3 in hepatocellular carcinoma involving the regulation of peroxisome proliferator-activated receptor gamma (PPARγ).
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 3
    Names
    chemokine-like factor super family 3
    chemokine-like factor superfamily member 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024217.3 → NP_077179.1  CKLF-like MARVEL transmembrane domain-containing protein 3

      See identical proteins and their annotated locations for NP_077179.1

      Status: VALIDATED

      Source sequence(s)
      AC121952
      Consensus CDS
      CCDS22577.1
      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Related
      ENSMUSP00000034343.5, ENSMUST00000034343.5
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105065993..105074304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531329.3 → XP_006531392.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006531392.1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    2. XM_030243740.2 → XP_030099600.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    3. XM_030243743.2 → XP_030099603.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    4. XM_030243741.1 → XP_030099601.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    5. XM_030243742.1 → XP_030099602.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    6. XM_036154257.1 → XP_036010150.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    7. XM_006531327.4 → XP_006531390.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006531390.1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Related
      ENSMUSP00000148682.2, ENSMUST00000212081.2
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    8. XM_006531326.2 → XP_006531389.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006531389.1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain

    9. XM_030243745.1 → XP_030099605.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam01284
      Location:4 → 101
      MARVEL; Membrane-associating domain

    10. XM_006531328.2 → XP_006531391.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006531391.1

      UniProtKB/Swiss-Prot
      A6H6B5, Q8BJU1, Q99LJ5, Q9D165
      UniProtKB/TrEMBL
      Q3TA49
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 149
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LJ5.1 GenPept UniProtKB/Swiss-Prot:Q99LJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous