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    Polr2h polymerase (RNA) II (DNA directed) polypeptide H [ Mus musculus (house mouse) ]

    Gene ID: 245841, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Polr2hprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Hprovided by MGI
    Primary source
    MGI:MGI:2384309
    See related
    Ensembl:ENSMUSG00000021018 AllianceGenome:MGI:2384309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 12.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B1; 16 12.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20536552..20541015)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20717826..20722272)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene STARR-seq mESC enhancer starr_40329 Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene STARR-positive B cell enhancer ABC_E1489 Neighboring gene STARR-seq mESC enhancer starr_40331 Neighboring gene thrombopoietin Neighboring gene chordin Neighboring gene predicted gene, 22741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
    2. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8248, MGC103049

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Names
    DNA-directed RNA polymerase II subunit H
    RNA polymerases I, II, and III subunit ABC3
    RPB17
    RPB8 homolog
    NP_001343352.1
    NP_001404166.1
    NP_001404167.1
    NP_663607.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356423.2 → NP_001343352.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010490
      UniProtKB/TrEMBL
      A0A338P6B4
      Related
      ENSMUSP00000155920.2, ENSMUST00000161038.2
      Conserved Domains (1) summary
      smart00658
      Location:1 → 111
      RPOL8c; RNA polymerase subunit 8

    2. NM_001417237.1 → NP_001404166.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010490

    3. NM_001417238.1 → NP_001404167.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT010490
      UniProtKB/TrEMBL
      A0A338P6M3
      Related
      ENSMUSP00000155895.2, ENSMUST00000231656.2

    4. NM_145632.3 → NP_663607.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1

      See identical proteins and their annotated locations for NP_663607.1

      Status: VALIDATED

      Source sequence(s)
      CT010490
      Consensus CDS
      CCDS28058.1
      UniProtKB/Swiss-Prot
      Q3TT30, Q923G2
      UniProtKB/TrEMBL
      A0A338P6I2
      Related
      ENSMUSP00000021405.8, ENSMUST00000021405.8
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    RNA

    1. NR_184434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT010490

    2. NR_184435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT010490

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20536552..20541015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_184436.1: Suppressed sequence

      Description
      NR_184436.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923G2.3 GenPept UniProtKB/Swiss-Prot:Q923G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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