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    Fnbp4 formin binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 55935, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fnbp4provided by MGI
    Official Full Name
    formin binding protein 4provided by MGI
    Primary source
    MGI:MGI:1860513
    See related
    Ensembl:ENSMUSG00000008200 AllianceGenome:MGI:1860513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP30; Fnbp30; mKIAA1014
    Summary
    Predicted to be located in nuclear speck. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FNBP4 (formin binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 22.6), CNS E11.5 (RPKM 22.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E1; 2 50.35 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90575793..90611365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90745454..90781021)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90481961-90482070 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90490258-90490559 Neighboring gene predicted gene, 39871 Neighboring gene STARR-positive B cell enhancer ABC_E7838 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90519352-90519653 Neighboring gene STARR-seq mESC enhancer starr_05093 Neighboring gene nucleoporin 160 Neighboring gene STARR-seq mESC enhancer starr_05095 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene mitochondrial carrier 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Ruivenkamp CA, et al. Nat Genet, 2002 Jul. PMID 12089527
    2. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. Zucconi A, et al. J Mol Biol, 2001 Apr 13. PMID 11292345
    3. A novel pro-Arg motif recognized by WW domains. Bedford MT, et al. J Biol Chem, 2000 Apr 7. PMID 10744724
    4. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Chan DC, et al. EMBO J, 1996 Mar 1. PMID 8605874, Free PMC Article
    5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formin-binding protein 4
    Names
    formin binding protein 30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421559.1 → NP_001408488.1  formin-binding protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL714026

    2. NM_001421560.1 → NP_001408489.1  formin-binding protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL714026

    3. NM_001421561.1 → NP_001408490.1  formin-binding protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL714026

    4. NM_001421562.1 → NP_001408491.1  formin-binding protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL714026

    5. NM_018828.3 → NP_061298.2  formin-binding protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL714026
      Consensus CDS
      CCDS16414.2
      UniProtKB/Swiss-Prot
      Q3TPA6, Q6ZQ03, Q8BNC8, Q9JHC1
      UniProtKB/TrEMBL
      A0A5F8MPU2
      Related
      ENSMUSP00000159108.2, ENSMUST00000238890.2
      Conserved Domains (2) summary
      cd00201
      Location:605 → 636
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:222 → 249
      WW; WW domain

    RNA

    1. NR_185311.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL714026

    2. NR_185312.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL714026

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90575793..90611365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162404.1 → XP_036018297.1  formin-binding protein 4 isoform X1

      Conserved Domains (1) summary
      cd00201
      Location:115 → 146
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RNA

    1. XR_001783149.3 RNA Sequence

    2. XR_003953674.2 RNA Sequence

    3. XR_004940671.1 RNA Sequence

    4. XR_004940672.1 RNA Sequence

    5. XR_004940673.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ03.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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