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    Nap1l4 nucleosome assembly protein 1-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 17955, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nap1l4provided by MGI
    Official Full Name
    nucleosome assembly protein 1-like 4provided by MGI
    Primary source
    MGI:MGI:1316687
    See related
    Ensembl:ENSMUSG00000059119 AllianceGenome:MGI:1316687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nap2; D7Wsu30e; 2810410H14Rik
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Involved in nucleosome assembly. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including extraembryonic component; liver; lung; placenta; and tongue. Orthologous to human NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 74.3), CNS E14 (RPKM 61.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 88.24 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143067316..143103698, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143513579..143549882, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 18 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene predicted gene, 23297 Neighboring gene STARR-positive B cell enhancer ABC_E1362 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene microRNA 7064 Neighboring gene STARR-seq mESC enhancer starr_20532 Neighboring gene STARR-seq mESC enhancer starr_20533 Neighboring gene predicted gene 15580

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Familial hypertrophic cardiomyopathy: man, mouse and cat. Baty C, et al. QJM, 1998 Dec. PMID 10024943
    2. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation. Dominguez F, et al. J Virol, 2021 Jul 26. PMID 34076483, Free PMC Article
    3. Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7. Purbowasito W, et al. DNA Res, 2004 Dec 31. PMID 15871462
    4. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. Nicholson RH, et al. Genomics, 2000 Aug 15. PMID 10950922
    5. The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Ghasemzadeh M, et al. Blood, 2013 May 30. PMID 23550035, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
      Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
    2. Leukocyte migration is initiated by homotypic adhesive interactions between platelets, leading to the development of an NAP-2 chemotactic gradient within the thrombus body that guides leukocytes to sites of vascular injury.
      Title: The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.
    3. Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
      Title: Interaction between nucleosome assembly protein 1-like family members.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome assembly protein 1-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285489.1 → NP_001272418.1  nucleosome assembly protein 1-like 4 isoform a

      See identical proteins and their annotated locations for NP_001272418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AJ002198, BC089018, BY073069
      Consensus CDS
      CCDS85479.1
      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Related
      ENSMUSP00000147130.2, ENSMUST00000208190.2
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    2. NM_001285490.1 → NP_001272419.1  nucleosome assembly protein 1-like 4 isoform a

      See identical proteins and their annotated locations for NP_001272419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AC068006, AJ002198, BC089018
      Consensus CDS
      CCDS85479.1
      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Related
      ENSMUSP00000146474.2, ENSMUST00000209098.2
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    3. NM_008672.3 → NP_032698.1  nucleosome assembly protein 1-like 4 isoform b

      See identical proteins and their annotated locations for NP_032698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AJ002198, BC089018, BQ746389, BY073069
      Consensus CDS
      CCDS40197.1
      UniProtKB/Swiss-Prot
      O88701, Q78ZA7
      UniProtKB/TrEMBL
      A2RSB1, Q8C1W9
      Related
      ENSMUSP00000072510.6, ENSMUST00000072727.7
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143067316..143103698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508507.4 → XP_006508570.1  nucleosome assembly protein 1-like 4 isoform X6

      Conserved Domains (1) summary
      pfam00956
      Location:67 → 293
      NAP; Nucleosome assembly protein (NAP)

    2. XM_030242206.2 → XP_030098066.1  nucleosome assembly protein 1-like 4 isoform X8

      Conserved Domains (1) summary
      pfam00956
      Location:67 → 293
      NAP; Nucleosome assembly protein (NAP)

    3. XM_006508506.4 → XP_006508569.1  nucleosome assembly protein 1-like 4 isoform X5

      UniProtKB/TrEMBL
      Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:67 → 303
      NAP; Nucleosome assembly protein (NAP)

    4. XM_030242205.2 → XP_030098065.1  nucleosome assembly protein 1-like 4 isoform X7

      Conserved Domains (1) summary
      pfam00956
      Location:67 → 303
      NAP; Nucleosome assembly protein (NAP)

    5. XM_036152762.1 → XP_036008655.1  nucleosome assembly protein 1-like 4 isoform X2

      UniProtKB/TrEMBL
      Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    6. XM_036152764.1 → XP_036008657.1  nucleosome assembly protein 1-like 4 isoform X4

      UniProtKB/TrEMBL
      Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    7. XM_030242203.2 → XP_030098063.1  nucleosome assembly protein 1-like 4 isoform X6

      Conserved Domains (1) summary
      pfam00956
      Location:67 → 293
      NAP; Nucleosome assembly protein (NAP)

    8. XM_036152759.1 → XP_036008652.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    9. XM_036152763.1 → XP_036008656.1  nucleosome assembly protein 1-like 4 isoform X3

      UniProtKB/Swiss-Prot
      O88701, Q78ZA7
      UniProtKB/TrEMBL
      A2RSB1, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    10. XM_030242200.2 → XP_030098060.1  nucleosome assembly protein 1-like 4 isoform X3

      UniProtKB/Swiss-Prot
      O88701, Q78ZA7
      UniProtKB/TrEMBL
      A2RSB1, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    11. XM_030242202.1 → XP_030098062.1  nucleosome assembly protein 1-like 4 isoform X3

      UniProtKB/Swiss-Prot
      O88701, Q78ZA7
      UniProtKB/TrEMBL
      A2RSB1, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    12. XM_030242204.1 → XP_030098064.1  nucleosome assembly protein 1-like 4 isoform X6

      Conserved Domains (1) summary
      pfam00956
      Location:67 → 293
      NAP; Nucleosome assembly protein (NAP)

    13. XM_006508504.4 → XP_006508567.1  nucleosome assembly protein 1-like 4 isoform X1

      See identical proteins and their annotated locations for XP_006508567.1

      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    14. XM_006508505.5 → XP_006508568.1  nucleosome assembly protein 1-like 4 isoform X1

      See identical proteins and their annotated locations for XP_006508568.1

      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    15. XM_036152761.1 → XP_036008654.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)

    16. XM_036152760.1 → XP_036008653.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/TrEMBL
      B7ZNL2, Q8C1W9
      Conserved Domains (1) summary
      pfam00956
      Location:65 → 338
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78ZA7.1 GenPept UniProtKB/Swiss-Prot:Q78ZA7

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