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    C4bp complement component 4 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12269, updated on 3-Apr-2024

    Summary

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    Official Symbol
    C4bpprovided by MGI
    Official Full Name
    complement component 4 binding proteinprovided by MGI
    Primary source
    MGI:MGI:88229
    See related
    Ensembl:ENSMUSG00000026405 AllianceGenome:MGI:88229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C4bpa
    Summary
    Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within complement activation, classical pathway and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 182.0) and liver adult (RPKM 75.8) See more
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    Genomic context

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    See C4bp in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130562510..130589365, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130635921..130661657, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene zona pellucida 3 receptor Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene STARR-seq mESC enhancer starr_02199 Neighboring gene predicted gene, 23623 Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1230 Neighboring gene YOD1 deubiquitinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation. Bierschenk D, et al. Front Immunol, 2023. PMID 37283747, Free PMC Article
    2. C4b binding protein negatively regulates TLR1/2 response. Morita N, et al. Innate Immun, 2017 Jan. PMID 27794068
    3. Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility. Nonaka MI, et al. Immunobiology, 2015 Apr. PMID 25468721, Free PMC Article
    4. Complement C4b-binding protein as a novel murine epididymal secretory protein. Nonaka MI, et al. Biol Reprod, 2003 Dec. PMID 12930719
    5. Murine binding protein of the fourth component of complement: structural polymorphism and its linkage to the major histocompatibility complex. Kaidoh T, et al. Proc Natl Acad Sci U S A, 1981 Jun. PMID 6943584, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation.
      Title: C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation.
    2. The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
      Title: The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
    3. Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2)
      Title: C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response.
    4. this study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production
      Title: C4b binding protein negatively regulates TLR1/2 response.
    5. These results suggest that EpC4BP is involved in male reproduction, but not essential for sperm maturation.
      Title: Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.
    6. The cellular uptake of C4BP depends on both heparan sulfate proteoglycans and CD91, involving interactions with positively charged residues within C4BP alpha-chain.
      Title: Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein.
    7. a novel function of C4BP as an epididymal secretory protein
      Title: Complement C4b-binding protein as a novel murine epididymal secretory protein.
    8. findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein
      Title: Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.
    9. C4BP prevents premature clearance of protein S and uses this ability to compensate the increased clearance of protein S-S460P.
      Title: In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of opsonization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to symbiotic bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C4b-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419982.1 → NP_001406911.1  C4b-binding protein isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231
      UniProtKB/Swiss-Prot
      P08607, Q91X48

    2. NM_001419983.1 → NP_001406912.1  C4b-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231

    3. NM_001419984.1 → NP_001406913.1  C4b-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231

    4. NM_001419986.1 → NP_001406915.1  C4b-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231

    5. NM_001419987.1 → NP_001406916.1  C4b-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231

    6. NM_001419988.1 → NP_001406917.1  C4b-binding protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231

    7. NM_007576.4 → NP_031602.3  C4b-binding protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_031602.3

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC139231
      Consensus CDS
      CCDS35700.1
      UniProtKB/Swiss-Prot
      P08607, Q91X48
      UniProtKB/TrEMBL
      Q3UW06
      Related
      ENSMUSP00000027657.8, ENSMUST00000027657.14
      Conserved Domains (3) summary
      PHA02831
      Location:290 → 420
      PHA02831; EEV host range protein; Provisional
      PHA02927
      Location:43 → 299
      PHA02927; secreted complement-binding protein; Provisional
      pfam18453
      Location:416 → 464
      C4bp_oligo; Oligomerization domain of C4b-binding protein alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130562510..130589365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247906.2 → XP_011246208.1  C4b-binding protein isoform X1

      See identical proteins and their annotated locations for XP_011246208.1

      UniProtKB/Swiss-Prot
      P08607, Q91X48
      UniProtKB/TrEMBL
      Q3UW06
      Conserved Domains (3) summary
      PHA02831
      Location:290 → 420
      PHA02831; EEV host range protein; Provisional
      PHA02927
      Location:43 → 299
      PHA02927; secreted complement-binding protein; Provisional
      pfam18453
      Location:416 → 464
      C4bp_oligo; Oligomerization domain of C4b-binding protein alpha
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08607.3 GenPept UniProtKB/Swiss-Prot:P08607

    Gene LinkOut

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