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    UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Homo sapiens (human) ]

    Gene ID: 7311, updated on 11-Apr-2024

    Summary

    Official Symbol
    UBA52provided by HGNC
    Official Full Name
    ubiquitin A-52 residue ribosomal protein fusion product 1provided by HGNC
    Primary source
    HGNC:HGNC:12458
    See related
    Ensembl:ENSG00000221983 MIM:191321; AllianceGenome:HGNC:12458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L40; CEP52; RPL40; HUBCEP52
    Summary
    Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 89.0), bone marrow (RPKM 83.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    19p13.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18563766..18577550)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18698806..18712614)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18682534..18688360)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18557131-18557659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18561006-18561812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18561813-18562619 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18566359-18566575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14321 Neighboring gene elongation factor for RNA polymerase II Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18579531-18580168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18587281-18588108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18589364-18590266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18594428-18594928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18594929-18595429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18596277-18596862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18605831-18606730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18611236-18612222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18618231-18619072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18631869-18632384 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18632385-18632900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18640318-18641203 Neighboring gene Sharpr-MPRA regulatory region 11651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18652136-18652636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10407 Neighboring gene FKBP prolyl isomerase 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18667707-18668498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18668499-18669288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18672913-18673498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18682001-18682677 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18683356-18684032 Neighboring gene KxDL motif containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18702459-18702982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18703866-18704367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10411 Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene required for excision 1-B domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18716731-18717649 Neighboring gene cytokine receptor like factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated ubiquitin A-52 residue ribosomal protein fusion product 1 protein (UBA52, ubiquitin-60S ribosomal protein L40) is incorporated into HIV-1 Gag virus-like particles PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of ubiquitin A-52 ribosomal protein fusion product 1 (UBA52, RPL40) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC57125, MGC126879, MGC126881

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle HDA PubMed 

    General protein information

    Preferred Names
    ubiquitin-ribosomal protein eL40 fusion protein
    Names
    ubiquitin carboxyl extension protein 52
    ubiquitin-52 amino acid fusion protein
    ubiquitin-60S ribosomal protein L40
    ubiquitin-CEP52

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023288.2 RefSeqGene

      Range
      13093..18786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033930.3NP_001029102.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001029102.1

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BQ428515, BQ428688, BU677484, CB124676
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000388107.1, ENST00000442744.7
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family
    2. NM_001321017.2NP_001307946.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BQ428515, BU677484, DA949569
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000472264.1, ENST00000596304.5
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family
    3. NM_001321018.2NP_001307947.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BG035502, BQ428515, BU677484, CD242660
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000470419.1, ENST00000595683.5
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family
    4. NM_001321019.2NP_001307948.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BG035502, BQ428515, BU677484, CD385706
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000471622.1, ENST00000595158.5
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family
    5. NM_001321020.2NP_001307949.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BE514609, BG035502, BQ428515, BU677484
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000472545.1, ENST00000598780.5
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family
    6. NM_001321021.1NP_001307950.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at an alternate start site, compared to variant 1. It encodes isoform 2, which has a longer N-terminus compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AC005253, AF545864, BG341101, BQ428515, BU677484
      UniProtKB/TrEMBL
      Q7Z4P3
      Conserved Domains (2) summary
      cd01803
      Location:883
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:86133
      Ribosomal_L40e; Ribosomal L40e family
    7. NM_001321022.2NP_001307951.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF545864, BG341101, BQ428515, BU677484, HY153317
      UniProtKB/TrEMBL
      Q7Z4P3
      Conserved Domains (2) summary
      pfam01020
      Location:5097
      Ribosomal_L40e; Ribosomal L40e family
      cl28922
      Location:147
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    8. NM_003333.5NP_003324.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_003324.1

      Status: REVIEWED

      Source sequence(s)
      AC005253, AF348700, AF545864, BQ428515, BQ428688, BU677484
      Consensus CDS
      CCDS12382.1
      UniProtKB/Swiss-Prot
      P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
      UniProtKB/TrEMBL
      Q3MIH3
      Related
      ENSP00000396910.1, ENST00000430157.6
      Conserved Domains (2) summary
      cd01803
      Location:176
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01020
      Location:79126
      Ribosomal_L40e; Ribosomal L40e family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      18563766..18577550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260054.2XP_005260111.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

      See identical proteins and their annotated locations for XP_005260111.1

      UniProtKB/TrEMBL
      M0R2S1
      Related
      ENSP00000472768.1, ENST00000596272.5
      Conserved Domains (3) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      pfam01020
      Location:78154
      Ribosomal_L40e; Ribosomal L40e family
    2. XM_006722871.3XP_006722934.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

      See identical proteins and their annotated locations for XP_006722934.1

      UniProtKB/TrEMBL
      M0R2S1
      Conserved Domains (3) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      pfam01020
      Location:78154
      Ribosomal_L40e; Ribosomal L40e family
    3. XM_005260052.3XP_005260109.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

      See identical proteins and their annotated locations for XP_005260109.1

      UniProtKB/TrEMBL
      M0R2S1
      Conserved Domains (3) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      pfam01020
      Location:78154
      Ribosomal_L40e; Ribosomal L40e family
    4. XM_005260053.4XP_005260110.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

      See identical proteins and their annotated locations for XP_005260110.1

      UniProtKB/TrEMBL
      M0R2S1
      Conserved Domains (3) summary
      cd01803
      Location:176
      Ubiquitin; Ubiquitin
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      pfam01020
      Location:78154
      Ribosomal_L40e; Ribosomal L40e family
    5. XM_017027198.2XP_016882687.2  ubiquitin-ribosomal protein eL40 fusion protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      18698806..18712614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321937.1XP_054177912.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    2. XM_054321936.1XP_054177911.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    3. XM_054321933.1XP_054177908.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    4. XM_054321934.1XP_054177909.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    5. XM_054321932.1XP_054177907.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X1