Tgtp1 T cell specific GTPase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgtp1provided by MGI
Official Full Name: T cell specific GTPase 1provided by MGI
Primary source: MGI:MGI:98734
See related: Ensembl:ENSMUSG00000078922 AllianceGenome:MGI:98734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtp2; Mg21; Tgtp; Irgb6; Tgtp2; Ifggb6
Summary: Enables GTPase activity. Involved in response to virus. Acts upstream of or within several processes, including cellular response to interferon-beta; response to interferon-alpha; and response to interferon-gamma. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; integumental system; nervous system; and nose. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 8.2), liver E18 (RPKM 7.6) and 17 other tissues See more
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Genomic context

Location:: 11 B1.2; 11 28.98 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (48876156..48883073, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (48985329..48992246, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
Title: Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tgtp (e-PCR), detects polymorphism
- UniSTS:472862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: T-cell-specific guanine nucleotide triphosphate-binding protein 1

Names: Interferon-gamma-inducible GTPase Ifggb6 protein; T-cell specific GTPase; T-cell-specific guanine nucleotide triphosphate-binding protein 2; interferon-gamma-inducible GTPase Ifggb5

NP_035709.3

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011579.3 → NP_035709.3 T-cell-specific guanine nucleotide triphosphate-binding protein 1

See identical proteins and their annotated locations for NP_035709.3

Status: VALIDATED

Source sequence(s)

AA177827, AK163978, AL627237, BY238768

Consensus CDS

CCDS24593.1

UniProtKB/Swiss-Prot

Q3T9E4, Q60711, Q62293, Q8BN19

UniProtKB/TrEMBL

A0A1G5SLN0, U5NJF8

Related

ENSMUSP00000069914.4, ENSMUST00000068063.4

Conserved Domains (2) summary

cd04104
Location:56 → 252

p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1

pfam05049
Location:22 → 395

IIGP; Interferon-inducible GTPase (IIGP)