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    Sh3rf1 SH3 domain containing ring finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 59009, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sh3rf1provided by MGI
    Official Full Name
    SH3 domain containing ring finger 1provided by MGI
    Primary source
    MGI:MGI:1913066
    See related
    Ensembl:ENSMUSG00000031642 AllianceGenome:MGI:1913066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Posh; Sh3md2; 2200003J05Rik
    Summary
    Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 9.0), lung adult (RPKM 8.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.1; 8 30.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61677117..61918327)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61224083..61465293)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene predicted gene, 18394 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene STARR-positive B cell enhancer ABC_E11383 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 1 Neighboring gene STARR-seq mESC enhancer starr_21581 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:63837915-63838110 Neighboring gene STARR-positive B cell enhancer mm9_chr8:63838783-63839083 Neighboring gene STARR-seq mESC enhancer starr_21584 Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene predicted gene, 40499 Neighboring gene predicted gene 10015 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10501 Neighboring gene STARR-seq mESC enhancer starr_21586 Neighboring gene STARR-seq mESC enhancer starr_21587 Neighboring gene predicted gene, 53435 Neighboring gene STARR-seq mESC enhancer starr_21588 Neighboring gene STARR-seq mESC enhancer starr_21589 Neighboring gene STARR-seq mESC enhancer starr_21591 Neighboring gene carbonyl reductase 4 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene STARR-seq mESC enhancer starr_21593 Neighboring gene predicted gene, 35254

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. POSH Regulates CD4+ T Cell Differentiation and Survival. Cunningham CA, et al. J Immunol, 2016 May 15. PMID 27084103, Free PMC Article
    2. Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. Kukekov NV, et al. J Biol Chem, 2006 Jun 2. PMID 16571722
    3. POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function. Yao M, et al. Cell Rep, 2022 Apr 5. PMID 35385725
    4. POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66. Dickson HM, et al. J Neurosci, 2010 Oct 6. PMID 20926658, Free PMC Article
    5. The scaffold protein POSH regulates axon outgrowth. Taylor J, et al. Mol Biol Cell, 2008 Dec. PMID 18829867, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
      Title: POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
    2. The pro-apoptotic JNK scaffold protein POSH mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
      Title: The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia.
    3. this study shows that POSH is essential for the integration of cell-type-specific signals that regulate the differentiation, survival, and function of T cells
      Title: POSH Regulates CD4+ T Cell Differentiation and Survival.
    4. identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.
      Title: The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
    5. a mechanism by which POSH regulates the localization of activated Rac1 and F-actin assembly to control PCDLP formation and subsequent somal translocation of migratory neurons.
      Title: POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
    6. An intracellular signaling pathway for process outgrowth inhibition by Nogo66 implicates the POSH complex as a therapeutic target to enhance axon outgrowth and plasticity in the injured central nervous system.
      Title: POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66.
    7. Results suggest that the molecular scaffold protein POSH assembles an inhibitory complex that links to the actin-myosin network to regulate neuronal process outgrowth.
      Title: The scaffold protein POSH regulates axon outgrowth.
    8. POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP apoptotic complex), that includes all of the known kinase components of the pathway.
      Title: Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs.
    9. Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway
      Title: Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of CD8-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SH3RF1
    Names
    RING-type E3 ubiquitin transferase SH3RF1
    SH3 domain-containing RING finger protein 1
    SH3 multiple domains 2
    SH3 multiple domains protein 2
    plenty of SH3 domains
    plenty of SH3s
    putative E3 ubiquitin-protein ligase SH3RF1
    NP_067481.2
    XP_011240533.1
    XP_036010097.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021506.3 → NP_067481.2  E3 ubiquitin-protein ligase SH3RF1

      Status: VALIDATED

      Source sequence(s)
      AC117196, AC134339
      Consensus CDS
      CCDS40348.1
      UniProtKB/Swiss-Prot
      O70254, Q3UG42, Q69ZI1, Q6P9M8, Q8BR66, Q8C2T5
      UniProtKB/TrEMBL
      E9QQ33
      Related
      ENSMUSP00000034060.6, ENSMUST00000034060.7
      Conserved Domains (5) summary
      cd11785
      Location:836 → 890
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11930
      Location:200 → 254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539 → 851
      PHA03247; large tegument protein UL36; Provisional
      cd16748
      Location:8 → 55
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:455 → 509
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61677117..61918327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242231.2 → XP_011240533.1  E3 ubiquitin-protein ligase SH3RF1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSY0
      Related
      ENSMUSP00000148118.2, ENSMUST00000209611.2
      Conserved Domains (5) summary
      cd11930
      Location:200 → 254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539 → 832
      PHA03247; large tegument protein UL36; Provisional
      cd00162
      Location:12 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17036
      Location:455 → 509
      SH3; Src Homology 3 domain superfamily
      cl17238
      Location:8 → 55
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_036154204.1 → XP_036010097.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

      UniProtKB/Swiss-Prot
      O70254, Q3UG42, Q69ZI1, Q6P9M8, Q8BR66, Q8C2T5
      UniProtKB/TrEMBL
      E9QQ33
      Conserved Domains (5) summary
      cd11785
      Location:836 → 890
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11930
      Location:200 → 254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539 → 851
      PHA03247; large tegument protein UL36; Provisional
      cd16748
      Location:8 → 55
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:455 → 509
      SH3; Src Homology 3 domain superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198678.1: Suppressed sequence

      Description
      NM_198678.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZI1.2 GenPept UniProtKB/Swiss-Prot:Q69ZI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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