U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vmn2r74 vomeronasal 2, receptor 74 [ Mus musculus (house mouse) ]

    Gene ID: 546980, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Vmn2r74provided by MGI
    Official Full Name
    vomeronasal 2, receptor 74provided by MGI
    Primary source
    MGI:MGI:3643877
    See related
    Ensembl:ENSMUSG00000090774 AllianceGenome:MGI:3643877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG546980
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Vmn2r74 in Genome Data Viewer
    Location:
    7 D3; 7 48.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (85601075..85610690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (85951867..85961482, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 73 Neighboring gene vomeronasal 2, receptor, pseudogene 78 Neighboring gene vomeronasal 2, receptor, pseudogene 79 Neighboring gene vomeronasal 2, receptor, pseudogene 80

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    vomeronasal receptor Vmn2r74

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384912.1 → NP_001371841.1  vomeronasal receptor Vmn2r74 precursor

      Status: VALIDATED

      Source sequence(s)
      AC107676, AC156557
      Consensus CDS
      CCDS52296.1
      UniProtKB/TrEMBL
      A0A3B2WBJ5, E9PW21
      Related
      ENSMUSP00000156918.2, ENSMUST00000232886.2
      Conserved Domains (3) summary
      cd15283
      Location:579 → 830
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:508 → 559
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:43 → 498
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      85601075..85610690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105187.1: Suppressed sequence

      Description
      NM_001105187.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools