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    Dcdc2c doublecortin domain containing 2C [ Mus musculus (house mouse) ]

    Gene ID: 68511, updated on 4-May-2024

    Summary

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    Official Symbol
    Dcdc2cprovided by MGI
    Official Full Name
    doublecortin domain containing 2Cprovided by MGI
    Primary source
    MGI:MGI:1915761
    See related
    Ensembl:ENSMUSG00000020633 AllianceGenome:MGI:1915761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110015M06Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and sperm flagellum. Predicted to be active in microtubule and microtubule organizing center. Orthologous to human DCDC2C (doublecortin domain containing 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 3.9) See more
    Orthologs
    human all
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    Genomic context

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    See Dcdc2c in Genome Data Viewer
    Location:
    12 A2; 12 10.94 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (28487794..28602941, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (28437795..28552942, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46326 Neighboring gene predicted gene, 25564 Neighboring gene allantoicase Neighboring gene collectin sub-family member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041
    2. The evolving doublecortin (DCX) superfamily. Reiner O, et al. BMC Genomics, 2006 Jul 26. PMID 16869982, Free PMC Article
    3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    doublecortin domain-containing protein 2C
    Names
    putative doublecortin domain-containing protein ENSP00000382097 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177964.2 → NP_001171435.2  doublecortin domain-containing protein 2C isoform 4

      See identical proteins and their annotated locations for NP_001171435.2

      Status: VALIDATED

      Source sequence(s)
      AC165283, AK003729
      UniProtKB/Swiss-Prot
      Q9D1B8
      Related
      ENSMUST00000189735.7
      Conserved Domains (1) summary
      cl28922
      Location:1 → 45
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001373956.1 → NP_001360885.1  doublecortin domain-containing protein 2C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC159197, AC165283
      UniProtKB/TrEMBL
      A0AA74KSJ0, A0AA74KT76
      Related
      ENSMUSP00000159704.1, ENSMUST00000249337.1
      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001373957.1 → NP_001360886.1  doublecortin domain-containing protein 2C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165283
      UniProtKB/Swiss-Prot
      Q9D1B8
      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. NM_001373958.1 → NP_001360887.1  doublecortin domain-containing protein 2C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165283
      UniProtKB/Swiss-Prot
      Q9D1B8
      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. NM_001412102.1 → NP_001399031.1  doublecortin domain-containing protein 2C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159197, AC165283
      UniProtKB/TrEMBL
      A0A1Y7VLK4
      Related
      ENSMUSP00000152233.2, ENSMUST00000221349.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      28487794..28602941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157602.1 → XP_036013495.1  doublecortin domain-containing protein 2C isoform X3

      Conserved Domains (1) summary
      cl28922
      Location:1 → 45
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_017315166.1 → XP_017170655.1  doublecortin domain-containing protein 2C isoform X1

      UniProtKB/TrEMBL
      A0AA74KT19
      Related
      ENSMUSP00000159706.1, ENSMUST00000249339.1
      Conserved Domains (1) summary
      cl28922
      Location:16 → 94
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_017315167.1 → XP_017170656.1  doublecortin domain-containing protein 2C isoform X2

      Conserved Domains (1) summary
      cl28922
      Location:1 → 45
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1B8.2 GenPept UniProtKB/Swiss-Prot:Q9D1B8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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