ADRA2A adrenoceptor alpha 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRA2Aprovided by HGNC
Official Full Name: adrenoceptor alpha 2Aprovided by HGNC
Primary source: HGNC:HGNC:281
See related: Ensembl:ENSG00000150594 MIM:104210; AllianceGenome:HGNC:281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADRA2; ADRAR; FPLD8; ZNF32; ADRA2R; ALPHA2AAR
Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
Orthologs: mouse all
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Genomic context

Location:: 10q25.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (111077029..111080907)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (111960874..111964752)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (112836787..112840665)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Scientific rationale for the use of alpha2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.
Title: Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders.
ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.
Title: ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.
The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.
Title: The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with attention deficit/hyperactivity disorder.
A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.
Title: A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.
The alpha2-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
Title: The α(2)-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
alpha2A- and alpha2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.
Title: α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.
Heteromerization between alpha2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Title: Heteromerization between α(2A) adrenoceptors and different polymorphic variants of the dopamine D(4) receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility.
Title: The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility.
RNA interference-mediated knockdown of the Drosophila ortholog of ADRA2A in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output.
Title: Discovering human diabetes-risk gene function with genetics and physiological assays.
Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders.
Title: Potential Role of ADRA2A Genetic Variants in the Etiology of ADHD Comorbid With Tic Disorders.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Lipodystrophy, familial partial, type 8 MedGen: CN376064 OMIM: 620679 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. EBI GWAS Catalog EBI GWAS CatalogPubMed
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA040321 (e-PCR)
- UniSTS:40025

GDB:193856 (e-PCR)
- UniSTS:155764

D10S1861 (e-PCR)
- UniSTS:39286

RH93859 (e-PCR)
- UniSTS:87259

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha-1B adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-2C adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha2-adrenergic receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables heterotrimeric G-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables thioesterase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in activation of protein kinase B activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fear response	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of calcium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion-dependent exocytosis	IC Inferred by Curator more info	PubMed
involved_in negative regulation of epinephrine secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of norepinephrine secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of norepinephrine secretion	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of uterine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in receptor transactivation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in thermoception	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dopaminergic synapse	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-2A adrenergic receptor

Names: adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR subtype C10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012020.1 RefSeqGene

Range

4998..8876

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_545

mRNA and Protein(s)

NM_000681.4 → NP_000672.3 alpha-2A adrenergic receptor

See identical proteins and their annotated locations for NP_000672.3

Status: REVIEWED

Source sequence(s)

AF284095, AL158163, BM682651

Consensus CDS

CCDS7569.2

UniProtKB/Swiss-Prot

B0LPF6, P08913, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1

Related

ENSP00000280155.2, ENST00000280155.4

Conserved Domains (2) summary

PHA03307
Location:244 → 389

PHA03307; transcriptional regulator ICP4; Provisional

cd15322
Location:49 → 452

7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors