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    Moxd1 monooxygenase, DBH-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294119, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Moxd1provided by RGD
    Official Full Name
    monooxygenase, DBH-like 1provided by RGD
    Primary source
    RGD:1310033
    See related
    Ensembl:ENSRNOG00000015321 AllianceGenome:RGD:1310033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in extracellular space and secretory granule membrane. Orthologous to human MOXD1 (monooxygenase DBH like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 62.4), Brain (RPKM 52.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Moxd1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (22894543..22984599, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (21075124..21165348, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (22124498..22206565, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553457 Neighboring gene uncharacterized LOC102553526 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 10 Neighboring gene ribosomal protein L36A, pseudogene 17 Neighboring gene uncharacterized LOC134484971 Neighboring gene uncharacterized LOC108349187 Neighboring gene syntaxin 7 Neighboring gene ribosomal protein S29, pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. Xin X, et al. J Biol Chem, 2004 Nov 12. PMID 15337741
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in norepinephrine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in octopamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DBH-like monooxygenase protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427764.1 → NP_001414693.1  DBH-like monooxygenase protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JUL0, G3V9S5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      22894543..22984599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_220095.10 → XP_220095.5  DBH-like monooxygenase protein 1 isoform X1

      Related
      ENSRNOP00000057945.1
      Conserved Domains (3) summary
      cd09631
      Location:68 → 202
      DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
      pfam01082
      Location:224 → 352
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:371 → 519
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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