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    Noa1 nitric oxide associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 56412, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Noa1provided by MGI
    Official Full Name
    nitric oxide associated 1provided by MGI
    Primary source
    MGI:MGI:1914306
    See related
    Ensembl:ENSMUSG00000036285 AllianceGenome:MGI:1914306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AtNOS1; mAtNOS1; 2610024G14Rik
    Summary
    Predicted to enable GTP binding activity. Involved in mitochondrial translation; regulation of cell death; and regulation of cellular respiration. Located in mitochondrial inner membrane. Is expressed in several structures, including humerus cartilage condensation; jaw; nervous system; otic capsule; and skeleton. Orthologous to human NOA1 (nitric oxide associated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.8), ovary adult (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.3; 5 41.64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (77442016..77458276, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (77294169..77310413, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:77666066-77666366 Neighboring gene predicted gene, 19060 Neighboring gene STARR-positive B cell enhancer ABC_E3585 Neighboring gene STARR-seq mESC enhancer starr_13466 Neighboring gene STARR-seq mESC enhancer starr_13469 Neighboring gene STARR-positive B cell enhancer mm9_chr5:77704983-77705284 Neighboring gene microRNA 5098 Neighboring gene RE1-silencing transcription factor Neighboring gene STARR-seq mESC enhancer starr_13474 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene insulin-like growth factor binding protein 7 Neighboring gene predicted gene, 34648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1. Al-Furoukh N, et al. Biochim Biophys Acta, 2013 Dec. PMID 23933583
    2. NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import. Al-Furoukh N, et al. PLoS One, 2014. PMID 25072814, Free PMC Article
    3. Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. Heidler J, et al. J Biol Chem, 2011 Sep 16. PMID 21771794, Free PMC Article
    4. mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells. Parihar A, et al. Life Sci, 2008 May 23. PMID 18456285
    5. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. Zemojtel T, et al. FEBS Lett, 2006 Jan 23. PMID 16380119

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with matrix side of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nitric oxide-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429035.1 → NP_001415964.1  nitric oxide-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141469

    2. NM_001429036.1 → NP_001415965.1  nitric oxide-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC141469

    3. NM_001429037.1 → NP_001415966.1  nitric oxide-associated protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC141469

    4. NM_001429038.1 → NP_001415967.1  nitric oxide-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC141469

    5. NM_001429039.1 → NP_001415968.1  nitric oxide-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC141469

    6. NM_001429040.1 → NP_001415969.1  nitric oxide-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC141469

    7. NM_019836.4 → NP_062810.1  nitric oxide-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062810.1

      Status: VALIDATED

      Source sequence(s)
      AC141469
      Consensus CDS
      CCDS19373.1
      UniProtKB/Swiss-Prot
      Q3T996, Q3U044, Q99JU4, Q9JJG9
      UniProtKB/TrEMBL
      Q8BMY1
      Related
      ENSMUSP00000045948.9, ENSMUST00000047860.9
      Conserved Domains (4) summary
      cd01855
      Location:180 → 396
      YqeH; Circularly permuted YqeH GTPase
      PRK13796
      Location:140 → 655
      PRK13796; GTPase YqeH; Provisional
      pfam11221
      Location:79 → 120
      Med21; Subunit 21 of Mediator complex
      pfam15444
      Location:33 → 129
      TMEM247; Transmembrane protein 247

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      77442016..77458276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535153.5 → XP_006535216.1  nitric oxide-associated protein 1 isoform X1

      Conserved Domains (3) summary
      cd01855
      Location:180 → 396
      YqeH; Circularly permuted YqeH GTPase
      TIGR03597
      Location:142 → 616
      GTPase_YqeH; ribosome biogenesis GTPase YqeH
      pfam15236
      Location:83 → 119
      CCDC66; Coiled-coil domain-containing protein 66

    2. XM_011249546.4 → XP_011247848.1  nitric oxide-associated protein 1 isoform X2

      Conserved Domains (2) summary
      cd01855
      Location:180 → 396
      YqeH; Circularly permuted YqeH GTPase
      pfam15236
      Location:83 → 119
      CCDC66; Coiled-coil domain-containing protein 66
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJG9.1 GenPept UniProtKB/Swiss-Prot:Q9JJG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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