Tra2a transformer 2 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tra2aprovided by MGI
Official Full Name: transformer 2 alphaprovided by MGI
Primary source: MGI:MGI:1933972
See related: Ensembl:ENSMUSG00000029817 AllianceGenome:MGI:1933972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mAWMS1; Tra2alpha; TRA2-alpha; TRA-2 alpha; 1500010G04Rik; G430041M01Rik
Summary: Enables identical protein binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; olfactory epithelium; and retina. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 66.1), CNS E14 (RPKM 56.3) and 24 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 B2.3; 6 23.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (49220855..49241182, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (49243921..49264248, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interaction of Tra2alpha with 9G8 and SRp30c appears to be crucial for ESE-dependent GnRH pre-mRNA splicing, allowing efficient generation of mature mRNA in GnRH-producing cells
Title: Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.
exonic splicing enhancer-dependent splicing of GnRH mRNA is mediated by tra2alpha
Title: Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI713502 (e-PCR)
- UniSTS:245060

BE136002 (e-PCR)
- UniSTS:207953

RH125353 (e-PCR)
- UniSTS:162175

RH44636 (e-PCR)
- UniSTS:89011

Tra2a (e-PCR), detects polymorphism
- UniSTS:479159

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: transformer-2 protein homolog alpha

Names: nuclear transformer-2 alpha; transformer 2 alpha homolog; transformer-2 protein homolog A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347209.2 → NP_001334138.1 transformer-2 protein homolog alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC158667

Consensus CDS

CCDS85044.1

UniProtKB/Swiss-Prot

Q6PFR5

UniProtKB/TrEMBL

A0A0N4SVC2

Related

ENSMUSP00000145039.2, ENSMUST00000204189.3

Conserved Domains (1) summary

cd12363
Location:116 → 195

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
NM_001362188.2 → NP_001349117.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667

Conserved Domains (1) summary

cd12363
Location:17 → 96

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
NM_001406117.1 → NP_001393046.1 transformer-2 protein homolog alpha isoform 4

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406118.1 → NP_001393047.1 transformer-2 protein homolog alpha isoform 5

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406119.1 → NP_001393048.1 transformer-2 protein homolog alpha isoform 6

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406120.1 → NP_001393049.1 transformer-2 protein homolog alpha isoform 7

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406121.1 → NP_001393050.1 transformer-2 protein homolog alpha isoform 8

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406122.1 → NP_001393051.1 transformer-2 protein homolog alpha isoform 9

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406123.1 → NP_001393052.1 transformer-2 protein homolog alpha isoform 10

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406124.1 → NP_001393053.1 transformer-2 protein homolog alpha isoform 11

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406125.1 → NP_001393054.1 transformer-2 protein homolog alpha isoform 12

Status: VALIDATED

Source sequence(s)

AC158667

Conserved Domains (1) summary

cd12363
Location:116 → 195

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
NM_001406126.1 → NP_001393055.1 transformer-2 protein homolog alpha isoform 13

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406127.1 → NP_001393056.1 transformer-2 protein homolog alpha isoform 14

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406128.1 → NP_001393057.1 transformer-2 protein homolog alpha isoform 15

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406129.1 → NP_001393058.1 transformer-2 protein homolog alpha isoform 16

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406130.1 → NP_001393059.1 transformer-2 protein homolog alpha isoform 17

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406131.1 → NP_001393060.1 transformer-2 protein homolog alpha isoform 18

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406132.1 → NP_001393061.1 transformer-2 protein homolog alpha isoform 19

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406133.1 → NP_001393062.1 transformer-2 protein homolog alpha isoform 20

Status: VALIDATED

Source sequence(s)

AC158667

Conserved Domains (1) summary

cd12363
Location:116 → 195

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
NM_001406134.1 → NP_001393063.1 transformer-2 protein homolog alpha isoform 21

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406135.1 → NP_001393064.1 transformer-2 protein homolog alpha isoform 22

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406136.1 → NP_001393065.1 transformer-2 protein homolog alpha isoform 23

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406137.1 → NP_001393066.1 transformer-2 protein homolog alpha isoform 24

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406138.1 → NP_001393067.1 transformer-2 protein homolog alpha isoform 25

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406139.1 → NP_001393068.1 transformer-2 protein homolog alpha isoform 26

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406140.1 → NP_001393069.1 transformer-2 protein homolog alpha isoform 27

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406141.1 → NP_001393070.1 transformer-2 protein homolog alpha isoform 28

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406142.1 → NP_001393071.1 transformer-2 protein homolog alpha isoform 29

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406143.1 → NP_001393072.1 transformer-2 protein homolog alpha isoform 30

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406144.1 → NP_001393073.1 transformer-2 protein homolog alpha isoform 31

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406145.1 → NP_001393074.1 transformer-2 protein homolog alpha isoform 32

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406146.1 → NP_001393075.1 transformer-2 protein homolog alpha isoform 33

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406147.1 → NP_001393076.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406149.1 → NP_001393078.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406150.1 → NP_001393079.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406151.1 → NP_001393080.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406152.1 → NP_001393081.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406153.1 → NP_001393082.1 transformer-2 protein homolog alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406154.1 → NP_001393083.1 transformer-2 protein homolog alpha isoform 34

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406155.1 → NP_001393084.1 transformer-2 protein homolog alpha isoform 34

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406156.1 → NP_001393085.1 transformer-2 protein homolog alpha isoform 34

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406157.1 → NP_001393086.1 transformer-2 protein homolog alpha isoform 34

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406158.1 → NP_001393087.1 transformer-2 protein homolog alpha isoform 36

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406159.1 → NP_001393088.1 transformer-2 protein homolog alpha isoform 37

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406160.1 → NP_001393089.1 transformer-2 protein homolog alpha isoform 37

Status: VALIDATED

Source sequence(s)

AC158667
NM_001406161.1 → NP_001393090.1 transformer-2 protein homolog alpha isoform 37

Status: VALIDATED

Source sequence(s)

AC158667
NM_198102.3 → NP_932770.2 transformer-2 protein homolog alpha isoform 1

See identical proteins and their annotated locations for NP_932770.2

Status: VALIDATED

Source sequence(s)

AC158667

Consensus CDS

CCDS39486.1

UniProtKB/Swiss-Prot

Q6PFR5

UniProtKB/TrEMBL

E9QP00

Related

ENSMUSP00000031841.8, ENSMUST00000031841.9

Conserved Domains (1) summary

cd12363
Location:116 → 195

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

49220855..49241182 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505243.1 → XP_006505306.1 transformer-2 protein homolog alpha isoform X4

UniProtKB/Swiss-Prot

Q6PFR5

Conserved Domains (1) summary

cd12363
Location:145 → 222

RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
XM_036165704.1 → XP_036021597.1 transformer-2 protein homolog alpha isoform X7

Conserved Domains (1) summary

cd12363
Location:17 → 96

RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins