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    Sfxn3 sideroflexin 3 [ Mus musculus (house mouse) ]

    Gene ID: 94280, updated on 22-Aug-2021

    Summary

    Official Symbol
    Sfxn3provided by MGI
    Official Full Name
    sideroflexin 3provided by MGI
    Primary source
    MGI:MGI:2137679
    See related
    Ensembl:ENSMUSG00000025212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in lung adult (RPKM 25.0), CNS E18 (RPKM 24.3) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sfxn3 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45035212..45044822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45046773..45056383)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45122066..45130873)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene predicted gene, 35782 Neighboring gene Kazal-type serine peptidase inhibitor domain 1 Neighboring gene predicted gene, 35867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of one-carbon metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in serine import into mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178012.1NP_001171483.1  sideroflexin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC132957, AI481047, BY723942
      Consensus CDS
      CCDS50448.1
      UniProtKB/Swiss-Prot
      Q91V61
      Related
      ENSMUSP00000107585.5, ENSMUST00000111954.11
      Conserved Domains (1) summary
      pfam03820
      Location:15288
      Mtc; Tricarboxylate carrier
    2. NM_001178013.1NP_001171484.1  sideroflexin-3 isoform 3

      See identical proteins and their annotated locations for NP_001171484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame segment in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC132957, AI481047, BY723942
      Consensus CDS
      CCDS50447.1
      UniProtKB/TrEMBL
      Q3U4F0
      Related
      ENSMUSP00000081537.7, ENSMUST00000084493.8
      Conserved Domains (1) summary
      pfam03820
      Location:15281
      Mtc; Tricarboxylate carrier
    3. NM_001362379.1NP_001349308.1  sideroflexin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132957, AI481047
      Conserved Domains (1) summary
      pfam03820
      Location:1230
      Mtc; Tricarboxylate carrier
    4. NM_001362380.1NP_001349309.1  sideroflexin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132957, AI481047
      Conserved Domains (1) summary
      pfam03820
      Location:1230
      Mtc; Tricarboxylate carrier
    5. NM_001362381.1NP_001349310.1  sideroflexin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132957, AI481047
      Consensus CDS
      CCDS29856.1
      Conserved Domains (1) summary
      pfam03820
      Location:15321
      Mtc; Tricarboxylate carrier
    6. NM_053197.4NP_444427.1  sideroflexin-3 isoform 1

      See identical proteins and their annotated locations for NP_444427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI481047, AK034514, BY723942, CK343762
      Consensus CDS
      CCDS29856.1
      UniProtKB/Swiss-Prot
      Q91V61
      Related
      ENSMUSP00000059419.6, ENSMUST00000062213.13
      Conserved Domains (1) summary
      pfam03820
      Location:15321
      Mtc; Tricarboxylate carrier

    RNA

    1. NR_155547.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132957, AI481047

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45035212..45044822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527493.3XP_006527556.1  sideroflexin-3 isoform X1

      See identical proteins and their annotated locations for XP_006527556.1

      UniProtKB/Swiss-Prot
      Q91V61
      Conserved Domains (1) summary
      pfam03820
      Location:15321
      Mtc; Tricarboxylate carrier
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