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    Akna AT-hook transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 100182, updated on 5-Mar-2024

    Summary

    Official Symbol
    Aknaprovided by MGI
    Official Full Name
    AT-hook transcription factorprovided by MGI
    Primary source
    MGI:MGI:2140340
    See related
    Ensembl:ENSMUSG00000039158 AllianceGenome:MGI:2140340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 37.5), thymus adult (RPKM 21.8) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4 B3; 4 33.96 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63285364..63328988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63367123..63411094, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 3 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor, opposite strand Neighboring gene predicted gene, 52742 Neighboring gene STARR-positive B cell enhancer ABC_E6185 Neighboring gene STARR-positive B cell enhancer ABC_E2692 Neighboring gene STARR-seq mESC enhancer starr_10437 Neighboring gene whirlin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63141720-63141921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63150850-63151053 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63205604-63205905 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 Neighboring gene predicted gene, 38592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC116630, mKIAA1968

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    microtubule organization protein AKNA
    Names
    AT-hook-containing transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045514.4NP_001038979.1  microtubule organization protein AKNA isoform 1

      See identical proteins and their annotated locations for NP_001038979.1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      Consensus CDS
      CCDS38777.1
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
      Related
      ENSMUSP00000041614.5, ENSMUST00000035724.5
      Conserved Domains (1) summary
      pfam12443
      Location:584681
      AKNA; AT-hook-containing transcription factor
    2. NM_001305432.2NP_001292361.1  microtubule organization protein AKNA isoform 1

      See identical proteins and their annotated locations for NP_001292361.1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      Consensus CDS
      CCDS38777.1
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
      Conserved Domains (1) summary
      pfam12443
      Location:584681
      AKNA; AT-hook-containing transcription factor
    3. NM_001426143.1NP_001413072.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    4. NM_001426144.1NP_001413073.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    5. NM_001426145.1NP_001413074.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    6. NM_001426146.1NP_001413075.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    7. NM_001426147.1NP_001413076.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    8. NM_001426148.1NP_001413077.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    9. NM_001426149.1NP_001413078.1  microtubule organization protein AKNA isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683828
    10. NM_001426150.1NP_001413079.1  microtubule organization protein AKNA isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683828
    11. NM_001426151.1NP_001413080.1  microtubule organization protein AKNA isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL683828

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63285364..63328988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163542.1XP_036019435.1  microtubule organization protein AKNA isoform X2

      Conserved Domains (1) summary
      pfam12443
      Location:584681
      AKNA; AT-hook-containing transcription factor
    2. XM_036163544.1XP_036019437.1  microtubule organization protein AKNA isoform X3

      Conserved Domains (1) summary
      pfam12443
      Location:584681
      AKNA; AT-hook-containing transcription factor
    3. XM_036163543.1XP_036019436.1  microtubule organization protein AKNA isoform X3

      Conserved Domains (1) summary
      pfam12443
      Location:584681
      AKNA; AT-hook-containing transcription factor