Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf13bprovided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 13bprovided by MGI
Primary source: MGI:MGI:1889411
See related: Ensembl:ENSMUSG00000010142 AllianceGenome:MGI:1889411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Taci; 1200009E08Rik
Summary: Acts upstream of or within B cell homeostasis; hematopoietic progenitor cell differentiation; and negative regulation of B cell proliferation. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in renal vasculature. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human TNFRSF13B (TNF receptor superfamily member 13B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 32.7), thymus adult (RPKM 12.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61017567..61040435)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61126283..61153170)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.
Title: TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA.
TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.
Title: TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.
B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.
Title: B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.
IkappaBNS-deficient B cells also displayed impaired upregulation of the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), which is essential for TI responses, and decreased sensitivity to TACI ligands upon stimulation.
Title: TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS.
TACI -/- mice are able to clear the infection and resist rechallenge infection.
Title: TACI Contributes to Plasmodium yoelii Host Resistance by Controlling T Follicular Helper Cell Response and Germinal Center Formation.
Data (including data from studies in knockout mice and cells from such mice) suggest that Taci in peritoneal and adipose tissue macrophages is involved in regulation of adipogenesis leading to obesity.
Title: TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI-dependent activation of transitional B cells
Title: Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.
results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection
Title: Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice.
this study shows that increased TACI expression in B cells derived from non-obese diabetic mice contributes to the pathogenesis of type 1 diabetes NOD mice
Title: Increased expression of TACI on NOD B cells results in germinal centre reaction anomalies, enhanced plasma cell differentiation and immunoglobulin production.
splenic B cells from TACI-deficient (TACI- / -) mice were unable to secrete IL-10 following TLR stimulation, and TACI- / - mice had undetectable basal serum concentrations of IL-10.
Title: The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489232

stSG609427 (e-PCR)
- UniSTS:449506

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 13B

Names: transmembrane activator and CAML interactor; transmembrane activator and calcium-modulating and cyclophilin ligand interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021349.3 → NP_067324.1 tumor necrosis factor receptor superfamily member 13B

See identical proteins and their annotated locations for NP_067324.1

Status: VALIDATED

Source sequence(s)

AL646093

Consensus CDS

CCDS24806.1

UniProtKB/Swiss-Prot

Q9DBZ3, Q9ET35

UniProtKB/TrEMBL

A5D8Y6, A5D8Y7

Related

ENSMUSP00000010286.2, ENSMUST00000010286.8

Conserved Domains (1) summary

cd13415
Location:6 → 209

TNFRSF13B; Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI)

RNA

NR_157295.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL646093

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61017567..61040435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533851.5 → XP_006533914.1 tumor necrosis factor receptor superfamily member 13B isoform X1

See identical proteins and their annotated locations for XP_006533914.1

UniProtKB/Swiss-Prot

Q9DBZ3, Q9ET35

UniProtKB/TrEMBL

A5D8Y6, A5D8Y7

Conserved Domains (1) summary

cd13415
Location:6 → 209

TNFRSF13B; Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI)