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    Lrrn1 leucine rich repeat protein 1, neuronal [ Mus musculus (house mouse) ]

    Gene ID: 16979, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lrrn1provided by MGI
    Official Full Name
    leucine rich repeat protein 1, neuronalprovided by MGI
    Primary source
    MGI:MGI:106038
    See related
    Ensembl:ENSMUSG00000034648 AllianceGenome:MGI:106038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NLRR-1; 2810047E21Rik
    Summary
    Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; embryo mesenchyme; lip; and sensory organ. Orthologous to human LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 59.2), ovary adult (RPKM 34.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrn1 in Genome Data Viewer
    Location:
    6 E1; 6 49.71 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (107506687..107547189)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (107529726..107570228)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16942 Neighboring gene peptidylprolyl isomerase A pseudogene 6_1128.1 Neighboring gene STARR-seq mESC enhancer starr_16943 Neighboring gene STARR-seq mESC enhancer starr_16944 Neighboring gene predicted gene, 34933 Neighboring gene STARR-seq mESC enhancer starr_16945 Neighboring gene STARR-seq mESC enhancer starr_16946 Neighboring gene STARR-seq mESC enhancer starr_16947 Neighboring gene predicted gene, 35017 Neighboring gene vomeronasal 1 receptor, pseudogene 37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Taguchi A, et al. Brain Res Mol Brain Res, 1996 Jan. PMID 8717337
    2. Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma. Satoh S, et al. Sci Rep, 2016 Sep 8. PMID 27604320, Free PMC Article
    3. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Aubert J, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 12923295, Free PMC Article
    4. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
    5. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.
      Title: Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.
    2. NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development.
      Title: Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.
    3. NLRR-1 is expressed in a subset of myotome cells.
      Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008516.4 → NP_032542.1  leucine-rich repeat neuronal protein 1 precursor

      See identical proteins and their annotated locations for NP_032542.1

      Status: VALIDATED

      Source sequence(s)
      AC155327, AK139965, AK160841
      Consensus CDS
      CCDS20399.1
      UniProtKB/Swiss-Prot
      Q3USY1, Q61809, Q69ZI0
      Related
      ENSMUSP00000037096.9, ENSMUST00000049285.10
      Conserved Domains (8) summary
      smart00082
      Location:371 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:11 → 273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:429 → 516
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:339 → 362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:531 → 600
      fn3; Fibronectin type III domain
      pfam13855
      Location:119 → 179
      LRR_8; Leucine rich repeat
      cl11960
      Location:431 → 516
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      107506687..107547189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61809.1 GenPept UniProtKB/Swiss-Prot:Q61809

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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