Clec7a C-type lectin domain family 7, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec7aprovided by MGI
Official Full Name: C-type lectin domain family 7, member aprovided by MGI
Primary source: MGI:MGI:1861431
See related: Ensembl:ENSMUSG00000079293 AllianceGenome:MGI:1861431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BGR; beta-GR; Clecsf12
Summary: Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. Is expressed in brain; gut; limb; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Broad expression in lung adult (RPKM 2.7), bladder adult (RPKM 1.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129438554..129449748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129461591..129472785, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Self-recognition through Dectin-1 exacerbates liver inflammation.
Title: Self-recognition through Dectin-1 exacerbates liver inflammation.
Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
Title: Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
Title: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
Dectin-1/CARD9 induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung.
Title: Dectin-1/CARD9 induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung.
Clec7a drives gut fungus-mediated host lipid deposition.
Title: Clec7a drives gut fungus-mediated host lipid deposition.
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-kappaB pathway.
Title: Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
beta-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease.
Title: β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease.
Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.
Title: Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.
Title: Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.
Title: Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.

Submit: New GeneRIF Correction See all GeneRIFs (132)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IBA Inferred from Biological aspect of Ancestor more info
enables (1->3)-beta-D-glucan binding	IDA Inferred from Direct Assay more info	PubMed
enables (1->3)-beta-D-glucan binding	ISO Inferred from Sequence Orthology more info
enables (1->3)-beta-D-glucan immune receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables opsonin binding	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
involved_in detection of fungus	ISO Inferred from Sequence Orthology more info
involved_in detection of molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of molecule of fungal origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of yeast	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of yeast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine production involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-23 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed
involved_in response to yeast	IDA Inferred from Direct Assay more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-type lectin domain family 7 member A

Names: C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; beta-glucan receptor; dectin-1; dendritic cell-associated C-type lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309637.2 → NP_001296566.1 C-type lectin domain family 7 member A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AA240643, AC138620, BY750022

Consensus CDS

CCDS85170.1

UniProtKB/Swiss-Prot

E9QPW2, Q6QLQ4, Q8K1L4, Q9JI50

UniProtKB/TrEMBL

V9GXI5

Related

ENSMUSP00000139167.2, ENSMUST00000184581.3

Conserved Domains (1) summary

cd03593
Location:74 → 197

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_020008.4 → NP_064392.2 C-type lectin domain family 7 member A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the longer transcript and encodes the longer, functional protein (isoform 1).

Source sequence(s)

AA240643, AC138620, AF262985, BY750022

UniProtKB/Swiss-Prot

E9QPW2, Q6QLQ4, Q8K1L4, Q9JI50

Conserved Domains (1) summary

cd03593
Location:119 → 242

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

NR_132130.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.

Source sequence(s)

AA240643, AC138620, BY750022

Related

ENSMUST00000195589.6