U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prmt8 protein arginine N-methyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 381813, updated on 21-Apr-2024

    Summary

    Official Symbol
    Prmt8provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 8provided by MGI
    Primary source
    MGI:MGI:3043083
    See related
    Ensembl:ENSMUSG00000030350 AllianceGenome:MGI:3043083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrmt1l3; Hrmt1l4
    Summary
    Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; protein homodimerization activity; and protein-arginine N-methyltransferase activity. Predicted to be involved in histone methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; and protein homooligomerization. Predicted to act upstream of or within methylation. Predicted to be anchored component of the cytoplasmic side of the plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; and lung. Orthologous to human PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 13.0), frontal lobe adult (RPKM 11.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6 F3; 6 62.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127665972..127746430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127689009..127769467, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8132 Neighboring gene STARR-positive B cell enhancer ABC_E3683 Neighboring gene predicted gene, 34148 Neighboring gene poly (ADP-ribose) polymerase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_17416 Neighboring gene STARR-positive B cell enhancer ABC_E2210 Neighboring gene STARR-positive B cell enhancer ABC_E9677 Neighboring gene calcium release activated channel regulator 2A Neighboring gene predicted gene, 38900 Neighboring gene STARR-seq mESC enhancer starr_17419 Neighboring gene RIKEN cDNA 4921513H07 gene Neighboring gene predicted gene, 40402 Neighboring gene microRNA 7233

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-arginine omega-N asymmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-arginine omega-N asymmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 8
    Names
    HMT1 hnRNP methyltransferase-like 3
    heterogeneous nuclear ribonucleoprotein methyltransferase-like 4
    heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
    protein arginine N-methyltransferase 4
    NP_958759.2
    XP_006506415.1
    XP_030111350.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201371.2NP_958759.2  protein arginine N-methyltransferase 8

      See identical proteins and their annotated locations for NP_958759.2

      Status: VALIDATED

      Source sequence(s)
      AC127373, BC060250
      Consensus CDS
      CCDS57449.1
      UniProtKB/Swiss-Prot
      Q6PAK3, Q7M6Z2
      Related
      ENSMUSP00000032500.9, ENSMUST00000032500.9
      Conserved Domains (1) summary
      cd02440
      Location:115215
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_157230.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127373

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      127665972..127746430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255490.1XP_030111350.1  protein arginine N-methyltransferase 8 isoform X1

      Conserved Domains (1) summary
      cd02440
      Location:27127
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006506352.4XP_006506415.1  protein arginine N-methyltransferase 8 isoform X1

      Conserved Domains (1) summary
      cd02440
      Location:27127
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...