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    Emp3 epithelial membrane protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 13732, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Emp3provided by MGI
    Official Full Name
    epithelial membrane protein 3provided by MGI
    Primary source
    MGI:MGI:1098729
    See related
    Ensembl:ENSMUSG00000040212 AllianceGenome:MGI:1098729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; H-4; Ymp; MI-35; HNMP-1
    Summary
    Predicted to be involved in bleb assembly and cell death. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including hemolymphoid system; meninges; skeleton; spinal component of peripheral nervous system; and spinal cord. Orthologous to human EMP3 (epithelial membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 256.9), ovary adult (RPKM 106.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45567447..45570850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45918023..45921426, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptogyrin 4 Neighboring gene STARR-positive B cell enhancer ABC_E1087 Neighboring gene transmembrane protein 143 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:53178126-53178235 Neighboring gene STARR-positive B cell enhancer ABC_E6547 Neighboring gene STARR-positive B cell enhancer ABC_E873 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene, 45983

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Kusumoto Y, et al. Cell Immunol, 2018 Feb. PMID 29269102
    2. Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Aherrahrou Z, et al. Physiol Genomics, 2007 Jan 17. PMID 16926270
    3. A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen. Luedtke B, et al. Immunogenetics, 2003 Aug. PMID 12845499
    4. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. Bolin LM, et al. J Neurosci, 1997 Jul 15. PMID 9204931, Free PMC Article
    5. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. Ben-Porath I, et al. Gene, 1996 Dec 12. PMID 8996089

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 
    • Not Applicable (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bleb assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epithelial membrane protein 3
    Names
    EMP-3
    hematopoietic neural membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146346.1 → NP_001139818.1  epithelial membrane protein 3

      See identical proteins and their annotated locations for NP_001139818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK146939, AV024057, U87948
      Consensus CDS
      CCDS21270.1
      UniProtKB/Swiss-Prot
      O35912, O88333, Q3UIF8
      Related
      ENSMUSP00000132519.2, ENSMUST00000164119.3
      Conserved Domains (1) summary
      cl21598
      Location:12 → 156
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_010129.2 → NP_034259.2  epithelial membrane protein 3

      See identical proteins and their annotated locations for NP_034259.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV024057, CK022835, U87948
      Consensus CDS
      CCDS21270.1
      UniProtKB/Swiss-Prot
      O35912, O88333, Q3UIF8
      Related
      ENSMUSP00000037289.6, ENSMUST00000038876.13
      Conserved Domains (1) summary
      cl21598
      Location:12 → 156
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45567447..45570850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35912.2 GenPept UniProtKB/Swiss-Prot:O35912

    Gene LinkOut

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