Cd163 CD163 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd163provided by MGI
Official Full Name: CD163 antigenprovided by MGI
Primary source: MGI:MGI:2135946
See related: Ensembl:ENSMUSG00000008845 AllianceGenome:MGI:2135946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD163v2; CD163v3
Summary: Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to act upstream of or within acute-phase response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including gut; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 2.3) and 20 other tissues See more
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Genomic context

Location:: 6 F2; 6 59.13 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (124281596..124307488)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (124304636..124330529)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
Title: TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-kappaB pathway.
Title: ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.
CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
Title: CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Title: Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Study observed macrophage-induced tumor cell proliferation in cocultures of human monocyte-derived macrophages and leiomyosarcoma and myxofibrosarcoma human and mouse cell lines, which was abrogated by silencing of CD163. Tumor development of sarcoma cells in CD163-deficient mice was significantly abrogated in comparison with wild-type mice.
Title: CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma.
CD163 has a role in angiogenesis and vascular permeability with inflammation in atherosclerosis
Title: CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
While it is unclear why CD163 deficiency is initially beneficial, the late injurious effects are consistent with the key anti-inflammatory role of CD163 in the recovery phase of tissue damage
Title: The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.
house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia
Title: A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.
In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.
Title: Monocyte CD163 is altered in association with diabetic complications: possible protective role.
During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation.
Title: CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: scavenger receptor cysteine-rich type 1 protein M130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170395.1 → NP_001163866.1 scavenger receptor cysteine-rich type 1 protein M130 isoform 1 precursor

See identical proteins and their annotated locations for NP_001163866.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC124470

Consensus CDS

CCDS51905.1

UniProtKB/TrEMBL

B7ZMW6

Related

ENSMUSP00000108160.3, ENSMUST00000112541.8

Conserved Domains (2) summary

smart00202
Location:719 → 819

SR; Scavenger receptor Cys-rich

pfam00530
Location:724 → 819

SRCR; Scavenger receptor cysteine-rich domain
NM_053094.2 → NP_444324.2 scavenger receptor cysteine-rich type 1 protein M130 isoform 2 precursor

See identical proteins and their annotated locations for NP_444324.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AC124470

Consensus CDS

CCDS20516.1

UniProtKB/Swiss-Prot

A6H691, Q2VLH5, Q2VLH6, Q99MX8

Related

ENSMUSP00000032234.3, ENSMUST00000032234.5

Conserved Domains (2) summary

smart00202
Location:719 → 819

SR; Scavenger receptor Cys-rich

pfam00530
Location:724 → 819

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

124281596..124307488

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506800.5 → XP_006506863.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X1

Conserved Domains (1) summary

smart00202
Location:691 → 791

SR; Scavenger receptor Cys-rich