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    Zmiz1 zinc finger, MIZ-type containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 328365, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Zmiz1provided by MGI
    Official Full Name
    zinc finger, MIZ-type containing 1provided by MGI
    Primary source
    MGI:MGI:3040693
    See related
    Ensembl:ENSMUSG00000007817 AllianceGenome:MGI:3040693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rai17; Zimp10; Gm10397; E330020C23; I920194n01
    Summary
    Predicted to enable SMAD binding activity and nuclear receptor coactivator activity. Involved in positive regulation of Notch signaling pathway and positive regulation of T cell differentiation. Acts upstream of or within several processes, including circulatory system development; positive regulation of fibroblast proliferation; and vitellogenesis. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human ZMIZ1 (zinc finger MIZ-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 35.4), limb E14.5 (RPKM 30.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 15.03 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25458299..25667167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25457875..25666743)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Zmiz1 opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_36211 Neighboring gene predicted gene, 41113 Neighboring gene STARR-seq mESC enhancer starr_36213 Neighboring gene predicted gene, 32645 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26273941-26274105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26336816-26337032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26336443-26336626 Neighboring gene STARR-positive B cell enhancer mm9_chr14:26346851-26347151 Neighboring gene microRNA 3075 Neighboring gene STARR-positive B cell enhancer mm9_chr14:26385131-26385431 Neighboring gene RIKEN cDNA 4931406H21 gene Neighboring gene VISTA enhancer mm1678 Neighboring gene STARR-seq mESC enhancer starr_36215 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26428962-26429115 Neighboring gene predicted gene, 32497 Neighboring gene STARR-seq mESC enhancer starr_36220 Neighboring gene immune system associated SCR family kinase partner Neighboring gene predicted gene, 52102 Neighboring gene RIKEN cDNA 1700054O19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:26513358-26513673 Neighboring gene peptidylprolyl isomerase F, opposite strand Neighboring gene peptidylprolyl isomerase F (cyclophilin F)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer. Rogers LM, et al. J Invest Dermatol, 2013 Jul. PMID 23426136, Free PMC Article
    2. Spatial and temporal expression of Zimp7 and Zimp10 PIAS-like proteins in the developing mouse embryo. Rodriguez-Magadán H, et al. Gene Expr Patterns, 2008 Feb. PMID 18053775
    3. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Wang Q, et al. Blood, 2018 Sep 20. PMID 30076146, Free PMC Article
    4. Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding. Alghamdi TA, et al. Mol Metab, 2022 Dec. PMID 36307047, Free PMC Article
    5. Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias. Rakowski LA, et al. Cancer Res, 2013 Jan 15. PMID 23161489, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zmiz1 is required for mature beta-cell function and mass expansion upon high fat feeding.
      Title: Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding.
    2. Zmiz1 is a context-specific cofactor for Notch1 during Notch/Myc-dependent thymocyte proliferation, whether normal or malignant.
      Title: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
    3. Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
      Title: Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer.
    4. we show that activated NOTCH1 and ZMIZ1 collaborate to induce T-ALL in mice.
      Title: Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
    5. Zimp10 is found in somatic cells, outside the testis cords and ceases to be expressed in the adult testis.
      Title: Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads.
    6. provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis
      Title: The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
    7. A physiological role for Zimp10 in regulating Smad3/4-mediated transcription is demonstrated in mouse embryonic fibroblasts.
      Title: The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyramidal neuron migration to cerebral cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MIZ domain-containing protein 1
    Names
    PIAS-like protein Zimp10
    retinoic acid induced 17
    retinoic acid-induced protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310666.1 → NP_001297595.1  zinc finger MIZ domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001297595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AK132106, AK138053, BC058646, BQ748452, BU059092
      Consensus CDS
      CCDS79280.1
      UniProtKB/Swiss-Prot
      Q6P1E1
      UniProtKB/TrEMBL
      Q3V215
      Related
      ENSMUSP00000007961.9, ENSMUST00000007961.15
      Conserved Domains (2) summary
      cd16791
      Location:740 → 787
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      cl26464
      Location:192 → 556
      Atrophin-1; Atrophin-1 family

    2. NM_183208.4 → NP_899031.2  zinc finger MIZ domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_899031.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132106, AK138053, BC065120, BQ748452, CF732350
      Consensus CDS
      CCDS26873.1
      UniProtKB/Swiss-Prot
      Q6P1E1, Q6PDK9, Q6PF85, Q8BW47
      Related
      ENSMUSP00000124863.2, ENSMUST00000162645.8
      Conserved Domains (3) summary
      PHA03247
      Location:119 → 546
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:746 → 793
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      pfam18028
      Location:8 → 100
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      25458299..25667167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519134.4 → XP_006519197.1  zinc finger MIZ domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:119 → 546
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:746 → 793
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      pfam18028
      Location:8 → 100
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

    2. XM_036158678.1 → XP_036014571.1  zinc finger MIZ domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:118 → 556
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:740 → 787
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      pfam18028
      Location:8 → 100
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

    3. XM_036158677.1 → XP_036014570.1  zinc finger MIZ domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P1E1, Q6PDK9, Q6PF85, Q8BW47
      Conserved Domains (3) summary
      PHA03247
      Location:119 → 546
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:746 → 793
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
      pfam18028
      Location:8 → 100
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain

    4. XM_030247864.2 → XP_030103724.1  zinc finger MIZ domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:61 → 439
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:622 → 669
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    5. XM_030247865.2 → XP_030103725.1  zinc finger MIZ domain-containing protein 1 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:68 → 432
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:616 → 663
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    6. XM_036158679.1 → XP_036014572.1  zinc finger MIZ domain-containing protein 1 isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:68 → 432
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:616 → 663
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    7. XM_030247863.2 → XP_030103723.1  zinc finger MIZ domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:61 → 439
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:622 → 669
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033402.2: Suppressed sequence

      Description
      NM_001033402.2: This RefSeq was temporarily suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1E1.1 GenPept UniProtKB/Swiss-Prot:Q6P1E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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