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    Esd esterase D/formylglutathione hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 13885, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Esdprovided by MGI
    Official Full Name
    esterase D/formylglutathione hydrolaseprovided by MGI
    Primary source
    MGI:MGI:95421
    See related
    Ensembl:ENSMUSG00000021996 AllianceGenome:MGI:95421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FGH; Es10; Es-10; sid478
    Summary
    Enables hydrolase activity, acting on ester bonds. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 38.8), placenta adult (RPKM 36.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D3; 14 39.38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (74969591..74988205)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (74732151..74750765)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 2A Neighboring gene STARR-positive B cell enhancer ABC_E5454 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 1 Neighboring gene predicted gene, 52135 Neighboring gene STARR-positive B cell enhancer ABC_E5455 Neighboring gene STARR-positive B cell enhancer ABC_E9901 Neighboring gene STARR-positive B cell enhancer ABC_E8571 Neighboring gene predicted gene 10847

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Polymorphism of esterase-10 in Mus musculus. Peters J, et al. Biochem Genet, 1976 Feb. PMID 1259699
    2. Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats. Ono T, et al. Jpn J Genet, 1995 Feb. PMID 7772379
    3. A new mutant hairless mouse with lymph node hyperplasia and late onset of autoimmune pathology. Massironi SM, et al. Braz J Med Biol Res, 1994 Oct. PMID 7640630
    4. Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Lukey T, et al. Biochem Genet, 1985 Apr. PMID 3925939
    5. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Leinwand L, et al. Cytogenet Cell Genet, 1978. PMID 206412

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic substance catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic substance catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase
    Names
    Sid 478
    esterase 10
    esterase D
    NP_001272352.1
    NP_058599.1
    XP_006518606.1
    XP_030103505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285423.1 → NP_001272352.1  S-formylglutathione hydrolase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154621
      Consensus CDS
      CCDS70603.1
      UniProtKB/TrEMBL
      H3BKH6, H3BLJ9
      Related
      ENSMUSP00000135394.2, ENSMUST00000176957.8
      Conserved Domains (2) summary
      PLN02442
      Location:15 → 294
      PLN02442; S-formylglutathione hydrolase
      COG0627
      Location:13 → 295
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]

    2. NM_016903.5 → NP_058599.1  S-formylglutathione hydrolase isoform 2

      See identical proteins and their annotated locations for NP_058599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC154621, AK010683, AK163074
      Consensus CDS
      CCDS36975.1
      UniProtKB/Swiss-Prot
      Q80ZX4, Q9CWI4, Q9R0P3
      UniProtKB/TrEMBL
      H3BLJ9
      Related
      ENSMUSP00000022573.11, ENSMUST00000022573.17
      Conserved Domains (2) summary
      PLN02442
      Location:2 → 281
      PLN02442; S-formylglutathione hydrolase
      COG0627
      Location:1 → 282
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      74969591..74988205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247645.1 → XP_030103505.1  S-formylglutathione hydrolase isoform X2

      UniProtKB/TrEMBL
      H3BK43, H3BLJ9
      Related
      ENSMUSP00000135244.2, ENSMUST00000175887.8
      Conserved Domains (1) summary
      cl21494
      Location:2 → 248
      Abhydrolase; alpha/beta hydrolases

    2. XM_006518543.3 → XP_006518606.1  S-formylglutathione hydrolase isoform X1

      UniProtKB/TrEMBL
      H3BLJ9
      Conserved Domains (1) summary
      cl21494
      Location:15 → 261
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0P3.1 GenPept UniProtKB/Swiss-Prot:Q9R0P3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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