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    Frmd6 FERM domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 319710, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Frmd6provided by MGI
    Official Full Name
    FERM domain containing 6provided by MGI
    Primary source
    MGI:MGI:2442579
    See related
    Ensembl:ENSMUSG00000048285 AllianceGenome:MGI:2442579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Willin; 2610019M19Rik; 4930488L10Rik
    Summary
    Acts upstream of or within apical constriction; cellular protein localization; and regulation of actin filament-based process. Located in apical junction complex. Is expressed in several structures, including lung; medulla oblongata basal plate; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human FRMD6 (FERM domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.7), limb E14.5 (RPKM 11.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C2; 12 29.37 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (70872235..70949009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70825456..70902234)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32322 Neighboring gene STARR-seq mESC enhancer starr_32397 Neighboring gene predicted gene, 40437 Neighboring gene STARR-seq mESC enhancer starr_32400 Neighboring gene predicted gene, 51973 Neighboring gene STARR-positive B cell enhancer ABC_E4027 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71954025-71954293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71974587-71974696 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:71981618-71981801 Neighboring gene STARR-seq mESC enhancer starr_32405 Neighboring gene STARR-seq mESC enhancer starr_32406 Neighboring gene predicted gene, 32664 Neighboring gene predicted gene, 46355 Neighboring gene STARR-positive B cell enhancer ABC_E8488 Neighboring gene ARP10 actin-related protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury. Lyu C, et al. Sci Rep, 2020 Feb 5. PMID 32024965, Free PMC Article
    2. The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin. Wang Z, et al. Aging Cell, 2019 Apr. PMID 30667167, Free PMC Article
    3. Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. Moleirinho S, et al. PLoS One, 2013. PMID 23593160, Free PMC Article
    4. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Narumiya H, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17462595
    5. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Ishiuchi T, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685893

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.
      Title: Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.
    2. The aged CMECs utilize BDNF-TrkB-T1 signalling to recruit Willin as a downstream effector to further activate the Hippo pathway, which then promotes migration.
      Title: The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin.
    3. results suggest that the nectin-afadin interaction plays a role in the correct localization of Willin
      Title: Nectins localize Willin to cell-cell junctions.
    4. Willin is predominantly expressed in fibroblasts and that Willin expression activates the Hippo signaling cascade
      Title: Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts.
    5. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
      Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apical constriction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418229.1 → NP_001405158.1  FERM domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132325, AC140360

    2. NM_001418230.1 → NP_001405159.1  FERM domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132325, AC140360

    3. NM_028127.4 → NP_082403.2  FERM domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_082403.2

      Status: VALIDATED

      Source sequence(s)
      AC132325, AC140360
      Consensus CDS
      CCDS25959.1
      UniProtKB/Swiss-Prot
      Q8BW34, Q8C0V9
      Related
      ENSMUSP00000052202.8, ENSMUST00000057859.9
      Conserved Domains (3) summary
      cd13185
      Location:227 → 335
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      pfam00373
      Location:123 → 234
      FERM_M; FERM central domain
      cl28922
      Location:15 → 120
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      70872235..70949009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515977.5 → XP_006516040.1  FERM domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006516040.1

      UniProtKB/Swiss-Prot
      Q8BW34, Q8C0V9
      Conserved Domains (3) summary
      cd13185
      Location:227 → 335
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      pfam00373
      Location:123 → 234
      FERM_M; FERM central domain
      cl28922
      Location:15 → 120
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006515979.5 → XP_006516042.1  FERM domain-containing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006516042.1

      Conserved Domains (3) summary
      smart00295
      Location:20 → 226
      B41; Band 4.1 homologues
      cd13185
      Location:219 → 327
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      cl28922
      Location:15 → 112
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_036157494.1 → XP_036013387.1  FERM domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q8BW34, Q8C0V9
      Conserved Domains (3) summary
      cd13185
      Location:227 → 335
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      pfam00373
      Location:123 → 234
      FERM_M; FERM central domain
      cl28922
      Location:15 → 120
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0V9.2 GenPept UniProtKB/Swiss-Prot:Q8C0V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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