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    Prr15 proline rich 15 [ Mus musculus (house mouse) ]

    Gene ID: 78004, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prr15provided by MGI
    Official Full Name
    proline rich 15provided by MGI
    Primary source
    MGI:MGI:1925254
    See related
    Ensembl:ENSMUSG00000045725 AllianceGenome:MGI:1925254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G90; E130201N16Rik
    Summary
    Is expressed in alimentary system; central nervous system; and olfactory epithelium. Orthologous to human PRR15 (proline rich 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 38.6), small intestine adult (RPKM 37.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B3; 6 26.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54290442..54320421)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54326756..54343436)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chimerin 2 Neighboring gene STARR-seq mESC enhancer starr_15947 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene predicted gene 15527 Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene predicted gene, 34169 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026 Neighboring gene secernin 1 Neighboring gene predicted gene, 52863

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of G90, a novel mouse RNA that lacks an extensive open reading frame. Krause R, et al. Gene, 1999 May 17. PMID 10333519
    2. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer. Guo F, et al. Cell Death Dis, 2023 Apr 18. PMID 37072408, Free PMC Article
    3. Preferential expression of the G90 gene in post-mitotic cells during mouse embryonic development. Meunier D, et al. Anat Embryol (Berl), 2003 Sep. PMID 12768423
    4. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. Feng W, et al. PLoS One, 2009 Dec 16. PMID 20016822, Free PMC Article
    5. Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Tenney AP, et al. Cell Rep, 2019 Oct 8. PMID 31597102, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
      Title: PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer.
    2. G90 expression and absence of proliferation were correlated in most of the cells showing expression of this gene during embryonic development in mice.
      Title: Preferential expression of the G90 gene in post-mitotic cells during mouse embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030024.3 → NP_084300.1  proline-rich protein 15

      See identical proteins and their annotated locations for NP_084300.1

      Status: VALIDATED

      Source sequence(s)
      AC084220
      Consensus CDS
      CCDS20155.1
      UniProtKB/Swiss-Prot
      Q9D1T5
      UniProtKB/TrEMBL
      A2RT92
      Related
      ENSMUSP00000049549.5, ENSMUST00000059138.6
      Conserved Domains (1) summary
      pfam15321
      Location:10 → 102
      ATAD4; ATPase family AAA domain containing 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54290442..54320421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152399.1 → XP_036008292.1  proline-rich protein 15 isoform X1

      UniProtKB/Swiss-Prot
      Q9D1T5
      UniProtKB/TrEMBL
      A2RT92
      Conserved Domains (1) summary
      pfam15321
      Location:10 → 102
      ATAD4; ATPase family AAA domain containing 4

    RNA

    1. XR_004933647.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1T5.1 GenPept UniProtKB/Swiss-Prot:Q9D1T5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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