Abi3 ABI family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abi3provided by MGI
Official Full Name: ABI family member 3provided by MGI
Primary source: MGI:MGI:1913860
See related: Ensembl:ENSMUSG00000018381 AllianceGenome:MGI:1913860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NESH; 2210414K06Rik
Summary: Predicted to enable SH3 domain binding activity and identical protein binding activity. Involved in defense response to tumor cell; negative regulation of lamellipodium assembly; and negative regulation of protein localization to plasma membrane. Located in lamellipodium. Part of SCAR complex. Is expressed in several structures, including genitourinary system; gut; heart ventricle; lung; and spleen. Orthologous to human ABI3 (ABI family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 38.5), duodenum adult (RPKM 25.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95720898..95733302, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95830072..95842476, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression.
Title: Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression.
The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies.
Title: The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies.
Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer's Disease Genetics and Neuropathology.
Title: Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer's Disease Genetics and Neuropathology.
Deletion of Abi3/Gngt2 influences age-progressive amyloid beta and tau pathologies in distinctive ways.
Title: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3-based WAVE2 complex.
Title: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L18035 (e-PCR)
- UniSTS:23193

AI987680 (e-PCR)
- UniSTS:165796

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ABI gene family member 3

Names: ABI gene family, member 3; new molecule including SH3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163464.1 → NP_001156936.1 ABI gene family member 3 isoform 2

See identical proteins and their annotated locations for NP_001156936.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences causes translation initiation at a downstream AUG and results an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK037144, AL593858

UniProtKB/Swiss-Prot

Q8BYZ1

Conserved Domains (2) summary

cd11826
Location:260 → 311

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:43 → 114

Abi_HHR; Abl-interactor HHR
NM_025659.4 → NP_079935.1 ABI gene family member 3 isoform 1

See identical proteins and their annotated locations for NP_079935.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK008928, AL593858

Consensus CDS

CCDS25283.1

UniProtKB/Swiss-Prot

Q3TA46, Q6PE63, Q8BYZ1, Q9D7S4

Related

ENSMUSP00000061893.4, ENSMUST00000059026.10

Conserved Domains (2) summary

cd11826
Location:313 → 364

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:96 → 159

Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

95720898..95733302 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246225.2 → XP_030102085.1 ABI gene family member 3 isoform X4

Conserved Domains (2) summary

cd11826
Location:312 → 363

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:96 → 167

Abi_HHR; Abl-interactor HHR
XM_030246228.2 → XP_030102088.1 ABI gene family member 3 isoform X6

Conserved Domains (2) summary

cd11826
Location:271 → 321

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:96 → 167

Abi_HHR; Abl-interactor HHR
XM_017314710.3 → XP_017170199.1 ABI gene family member 3 isoform X7

UniProtKB/Swiss-Prot

Q8BYZ1

Conserved Domains (2) summary

cd11826
Location:260 → 311

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:43 → 114

Abi_HHR; Abl-interactor HHR
XM_017314709.2 → XP_017170198.1 ABI gene family member 3 isoform X3

Conserved Domains (2) summary

cd11826
Location:328 → 379

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:112 → 183

Abi_HHR; Abl-interactor HHR
XM_006533956.3 → XP_006534019.1 ABI gene family member 3 isoform X5

Conserved Domains (2) summary

cd11826
Location:288 → 338

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:112 → 183

Abi_HHR; Abl-interactor HHR
XM_017314708.1 → XP_017170197.1 ABI gene family member 3 isoform X2

Conserved Domains (2) summary

cd11826
Location:328 → 379

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:112 → 183

Abi_HHR; Abl-interactor HHR
XM_017314707.1 → XP_017170196.1 ABI gene family member 3 isoform X1

Conserved Domains (2) summary

cd11826
Location:329 → 380

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:112 → 183

Abi_HHR; Abl-interactor HHR