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    Tchp trichoplein, keratin filament binding [ Mus musculus (house mouse) ]

    Gene ID: 77832, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tchpprovided by MGI
    Official Full Name
    trichoplein, keratin filament bindingprovided by MGI
    Primary source
    MGI:MGI:1925082
    See related
    Ensembl:ENSMUSG00000002486 AllianceGenome:MGI:1925082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930031F18Rik
    Summary
    Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Predicted to act upstream of or within cell projection organization. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 10.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 55.99 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114845813..114860388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114707779..114722327)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2757 Neighboring gene transient receptor potential cation channel, subfamily V, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9261 Neighboring gene STARR-seq mESC enhancer starr_14082 Neighboring gene glycolipid transfer protein Neighboring gene STARR-positive B cell enhancer ABC_E10341 Neighboring gene predicted gene, 34931 Neighboring gene microRNA 7028 Neighboring gene GIT ArfGAP 2 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene ankyrin repeat domain 13a Neighboring gene STARR-seq mESC enhancer starr_14089

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis. Yamakawa D, et al. Cell Rep, 2021 Mar 9. PMID 33691104
    2. Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, et al. EMBO Rep, 2020 Jul 3. PMID 32337819, Free PMC Article
    3. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. Fassan M, et al. PLoS One, 2011 May 6. PMID 21573075, Free PMC Article
    4. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Ibi M, et al. J Cell Sci, 2011 Mar 15. PMID 21325031
    5. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. Inaba H, et al. J Cell Biol, 2016 Feb 15. PMID 26880200, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
      Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
    2. MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.
      Title: Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trichoplein keratin filament-binding protein
    Names
    mitochondrial protein with oncostatic activity
    mitostatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029992.2 → NP_084268.2  trichoplein keratin filament-binding protein

      See identical proteins and their annotated locations for NP_084268.2

      Status: VALIDATED

      Source sequence(s)
      AK020912, AK159947, BC043048, BU512279
      Consensus CDS
      CCDS51624.1
      UniProtKB/Swiss-Prot
      Q3TVW5, Q80ZV6, Q8C459, Q9CTP0
      Related
      ENSMUSP00000092009.5, ENSMUST00000094441.11
      Conserved Domains (1) summary
      pfam13868
      Location:145 → 479
      TPH; Trichohyalin-plectin-homology domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114845813..114860388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530508.4 → XP_006530571.1  trichoplein keratin filament-binding protein isoform X1

      Conserved Domains (1) summary
      pfam13868
      Location:83 → 420
      TPH; Trichohyalin-plectin-homology domain

    2. XM_036165613.1 → XP_036021506.1  trichoplein keratin filament-binding protein isoform X3

      Conserved Domains (1) summary
      pfam13868
      Location:4 → 223
      TPH; Trichohyalin-plectin-homology domain

    3. XM_006530510.5 → XP_006530573.1  trichoplein keratin filament-binding protein isoform X3

      See identical proteins and their annotated locations for XP_006530573.1

      UniProtKB/Swiss-Prot
      Q3TVW5
      Conserved Domains (1) summary
      pfam13868
      Location:4 → 223
      TPH; Trichohyalin-plectin-homology domain

    4. XM_006530511.5 → XP_006530574.1  trichoplein keratin filament-binding protein isoform X2

      Conserved Domains (1) summary
      pfam13868
      Location:1 → 282
      TPH; Trichohyalin-plectin-homology domain

    RNA

    1. XR_004942586.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TVW5.2 GenPept UniProtKB/Swiss-Prot:Q3TVW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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