Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina5provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 5provided by MGI
Primary source: MGI:MGI:107817
See related: Ensembl:ENSMUSG00000041550 AllianceGenome:MGI:107817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pci; PAI-3; 4933415L04
Summary: Predicted to enable several functions, including enzyme binding activity; phosphatidylcholine binding activity; and retinoic acid binding activity. Involved in spermatogenesis. Predicted to be located in several cellular components, including extracellular exosome; platelet dense tubular network; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Is expressed in several structures, including epithelium; genitourinary system; gut; musculoskeletal system; and skin. Orthologous to human SERPINA5 (serpin family A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 21.0), testis adult (RPKM 16.6) and 2 other tissues See more
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Genomic context

Location:: 12 E; 12 53.3 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104065572..104072397)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104099313..104106138)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the Fertilisation Ability of Mouse Sperm.
Title: SERPINA5 Protein in Cumulus-Oocyte Complexes Increases the Fertilisation Ability of Mouse Sperm.
role of PCI not only for the function and/or maturation of macrophages, but also as a negative regulator of apoptotic cell and activated platelets removal
Title: Protein C inhibitor (PCI) binds to phosphatidylserine exposing cells with implications in the phagocytosis of apoptotic cells and activated platelets.
The expression pattern of PCI throughout mouse development was mapped using in situ hybridization and immunohistochemistry.
Title: Expression patterns of protein C inhibitor in mouse development.
In testes of wild type males PCI is detected in spermatocytes of prophase I, as well as in late spermatids and mature spermatozoa, but it is absent from somatic cells.
Title: Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice.
The reactions with thrombin or APC of recombinant alpha(1)-PI M358R variants with or without the HCII extension were characterized electrophoretically and kinetically
Title: The appended tail region of heparin cofactor II and additional reactive centre loop mutations combine to increase the reactivity and specificity of alpha1-proteinase inhibitor M358R for thrombin.
PCI exerts a procoagulant and proinflammatory effect by inhibiting APC
Title: Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acrosin binding	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-KLK3 complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-PLAT complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-PLAU complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-TMPRSS11E complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-TMPRSS7 complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor V complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor XI complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor Xa complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-plasma kallikrein complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-thrombin complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma serine protease inhibitor

Names: PAI3; alpha-1 antiproteinase; antitrypsin; plasminogen activator inhibitor-3; protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A, member 5; serpin A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172953.3 → NP_766541.2 plasma serine protease inhibitor precursor

See identical proteins and their annotated locations for NP_766541.2

Status: VALIDATED

Source sequence(s)

AK077160, AK087714

Consensus CDS

CCDS26146.1

UniProtKB/Swiss-Prot

P70458, Q5BKQ8, Q8BU50

UniProtKB/TrEMBL

Q8BVN1

Related

ENSMUSP00000021495.4, ENSMUST00000021495.4

Conserved Domains (1) summary

cd19553
Location:42 → 405

serpinA5_PCI; serpin family A member 5, protein C inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

104065572..104072397

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515916.2 → XP_006515979.1 plasma serine protease inhibitor isoform X1

See identical proteins and their annotated locations for XP_006515979.1

UniProtKB/Swiss-Prot

P70458, Q5BKQ8, Q8BU50

UniProtKB/TrEMBL

Q8BVN1

Conserved Domains (1) summary

cd19553
Location:42 → 405

serpinA5_PCI; serpin family A member 5, protein C inhibitor