Mex3a mex3 RNA binding family member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mex3aprovided by MGI
Official Full Name: mex3 RNA binding family member Aprovided by MGI
Primary source: MGI:MGI:1919890
See related: Ensembl:ENSMUSG00000074480 AllianceGenome:MGI:1919890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm411; Rkhd4; 2700083E18Rik
Summary: Predicted to enable RNA binding activity. Predicted to be located in P-body and cytosol. Is expressed in central nervous system and sensory organ. Orthologous to human MEX3A (mex-3 RNA binding family member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 31.3), CNS E14 (RPKM 29.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.86 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88439253..88448701)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88531946..88541394)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
Title: Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis.
Title: Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis.
Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.
Title: Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.
The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma.
Title: The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma.
MEX3A regulates Lgr5(+) stem cell maintenance in the developing intestinal epithelium.
Title: MEX3A regulates Lgr5(+) stem cell maintenance in the developing intestinal epithelium.
Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.
Title: Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Mex3a (e-PCR), detects polymorphism
- UniSTS:478981

NoName (e-PCR)
- UniSTS:234722

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein MEX3A

Names: mex3 homolog A; ring finger and KH domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029890.3 → NP_001025061.2 RNA-binding protein MEX3A

Status: VALIDATED

Source sequence(s)

AC145168

UniProtKB/TrEMBL

G3UYU0

Related

ENSMUSP00000134222.2, ENSMUST00000172699.2

Conserved Domains (3) summary

smart00322
Location:223 → 288

KH; K homology RNA-binding domain

cd00105
Location:133 → 193

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam13920
Location:465 → 508

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)