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    Mrps33 mitochondrial ribosomal protein S33 [ Mus musculus (house mouse) ]

    Gene ID: 14548, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrps33provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S33provided by MGI
    Primary source
    MGI:MGI:1338046
    See related
    Ensembl:ENSMUSG00000029918 AllianceGenome:MGI:1338046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdap3; PTD003; CGI-139; MRP-S33
    Summary
    Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and lung. Orthologous to human MRPS33 (mitochondrial ribosomal protein S33). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 30.3), CNS E14 (RPKM 30.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B1; 6 18.67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39778738..39787870, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39801804..39810936, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_15669 Neighboring gene STARR-seq mESC enhancer starr_15670 Neighboring gene STARR-seq mESC enhancer starr_15671 Neighboring gene STARR-positive B cell enhancer ABC_E6425 Neighboring gene predicted gene 7554 Neighboring gene aldolase A, fructose-bisphosphate pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. Liu H, et al. J Neurochem, 1999 May. PMID 10217254
    2. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
    3. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
      Title: SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106490

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS33
    Names
    28S ribosomal protein S33, mitochondrial
    S33mt
    ganglioside-induced differentiation-associated-protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010930.1 → NP_001010930.1  small ribosomal subunit protein mS33 isoform 2

      See identical proteins and their annotated locations for NP_001010930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the coding region, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus.
      Source sequence(s)
      AI841153, BC028645, BU695761, BY296250
      Consensus CDS
      CCDS39464.1
      UniProtKB/TrEMBL
      Q8R2K5
      Related
      ENSMUSP00000110445.2, ENSMUST00000114797.2
      Conserved Domains (1) summary
      pfam08293
      Location:6 → 33
      MRP-S33; Mitochondrial ribosomal subunit S27

    2. NM_010270.2 → NP_034400.1  small ribosomal subunit protein mS33 isoform 1

      See identical proteins and their annotated locations for NP_034400.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI841153, AK019000, BU695761, BY296250
      Consensus CDS
      CCDS20026.1
      UniProtKB/Swiss-Prot
      O88743, Q9D2R8
      UniProtKB/TrEMBL
      Q58DZ5
      Related
      ENSMUSP00000031978.9, ENSMUST00000031978.9
      Conserved Domains (1) summary
      pfam08293
      Location:6 → 96
      MRP-S33; Mitochondrial ribosomal subunit S27

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39778738..39787870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2R8.1 GenPept UniProtKB/Swiss-Prot:Q9D2R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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