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    Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 230837, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asap3provided by MGI
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 3provided by MGI
    Primary source
    MGI:MGI:2684986
    See related
    Ensembl:ENSMUSG00000036995 AllianceGenome:MGI:2684986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm140; UPLC1; Ddefl1; 9430088F20Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cell migration; positive regulation of GTPase activity; and regulation of stress fiber assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in focal adhesion; intracellular membrane-bounded organelle; and ruffle. Orthologous to human ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 6.1), mammary gland adult (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asap3 in Genome Data Viewer
    Location:
    4 D3; 4 68.34 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135933662..135973888)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136206350..136246577)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4687 Neighboring gene STARR-seq mESC enhancer starr_11745 Neighboring gene inhibitor of DNA binding 3 Neighboring gene STARR-positive B cell enhancer ABC_E10267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene E2F transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene zinc finger protein 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. Qian J, et al. Signal Transduct Target Ther, 2017. PMID 29263912, Free PMC Article
    2. ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. Ha VL, et al. J Biol Chem, 2008 May 30. PMID 18400762, Free PMC Article
    3. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. Garrett-Engele CM, et al. PLoS Genet, 2007 Dec. PMID 18069898, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
      Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102639

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
    Names
    development and differentiation enhancing factor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008232.2 → NP_001008233.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001008233.1

      Status: VALIDATED

      Source sequence(s)
      AL935264, BC085250
      Consensus CDS
      CCDS18802.1
      UniProtKB/Swiss-Prot
      Q5U464
      Related
      ENSMUSP00000041899.8, ENSMUST00000047526.8
      Conserved Domains (7) summary
      cd07640
      Location:35 → 243
      BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
      cd00204
      Location:585 → 673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:294 → 400
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:307 → 390
      PH; PH domain
      pfam01412
      Location:427 → 541
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:588 → 641
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:550 → 583
      ANK; ANK repeat [structural motif]

    2. NM_001355698.1 → NP_001342627.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL935264, BC085250
      Conserved Domains (4) summary
      cd00204
      Location:312 → 400
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:21 → 127
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:277 → 310
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:154 → 268
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135933662..135973888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538761.3 → XP_006538824.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1

      Conserved Domains (5) summary
      cd07640
      Location:2 → 209
      BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
      COG0666
      Location:549 → 646
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13251
      Location:260 → 366
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:516 → 549
      ANK; ANK repeat [structural motif]
      cd17900
      Location:389 → 512
      ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)

    2. XM_011250233.4 → XP_011248535.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2

      Conserved Domains (5) summary
      COG0666
      Location:542 → 639
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13251
      Location:253 → 359
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:509 → 542
      ANK; ANK repeat [structural motif]
      cd17900
      Location:382 → 505
      ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
      cl12013
      Location:3 → 202
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_390738.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U464.1 GenPept UniProtKB/Swiss-Prot:Q5U464

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