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    C2cd2 C2 calcium-dependent domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 207781, updated on 5-Mar-2024

    Summary

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    Official Symbol
    C2cd2provided by MGI
    Official Full Name
    C2 calcium-dependent domain containing 2provided by MGI
    Primary source
    MGI:MGI:1891883
    See related
    Ensembl:ENSMUSG00000045975 AllianceGenome:MGI:1891883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF25; mKIAA4045; 5730563M15; 5830404H04Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 11.5), placenta adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C4; 16 57.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97656409..97727248, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97855209..97925795, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene receptor-interacting serine-threonine kinase 4 Neighboring gene STARR-seq mESC enhancer starr_41639 Neighboring gene PR domain containing 15 Neighboring gene STARR-seq mESC enhancer starr_41640 Neighboring gene microRNA 6964 Neighboring gene zinc finger and BTB domain containing 21 Neighboring gene predicted gene, 53924 Neighboring gene RIKEN cDNA C030010L15 gene Neighboring gene RIKEN cDNA B230307C23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Akeson EC, et al. Cytogenet Cell Genet, 2001. PMID 11528125
    2. Evolutionary breakpoints on human chromosome 21. Davisson MT, et al. Genomics, 2001 Nov. PMID 11707078
    3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4045

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174847.2 → NP_777272.2  C2 domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AA024193, AA137897, AK077731, AK080956, AK086520, AK220454, AV241091, BB005022, CB202385, CF616821, CF734597
      Consensus CDS
      CCDS28361.1
      UniProtKB/Swiss-Prot
      E9Q3C1, Q3TE01, Q3UP20, Q5DTR6, Q80XM8
      Related
      ENSMUSP00000127368.2, ENSMUST00000170757.3
      Conserved Domains (2) summary
      cd21682
      Location:53 → 230
      SMP_C2CD2; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2 (C2CD2)
      cl14603
      Location:261 → 386
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      97656409..97727248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246109.4 → XP_011244411.1  C2 domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      pfam18696
      Location:71 → 221
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:260 → 385
      C2; C2 domain

    2. XM_036159830.1 → XP_036015723.1  C2 domain-containing protein 2 isoform X3

      Conserved Domains (2) summary
      pfam18696
      Location:71 → 223
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:261 → 386
      C2; C2 domain

    3. XM_036159829.1 → XP_036015722.1  C2 domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam18696
      Location:71 → 223
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:261 → 386
      C2; C2 domain

    4. XM_011246111.2 → XP_011244413.1  C2 domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl14603
      Location:59 → 184
      C2; C2 domain

    5. XM_017316901.3 → XP_017172390.1  C2 domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      pfam18696
      Location:71 → 222
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cl14603
      Location:261 → 386
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q3C1.1 GenPept UniProtKB/Swiss-Prot:E9Q3C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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