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    Wfdc6b WAP four-disulfide core domain 6B [ Mus musculus (house mouse) ]

    Gene ID: 433502, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Wfdc6bprovided by MGI
    Official Full Name
    WAP four-disulfide core domain 6Bprovided by MGI
    Primary source
    MGI:MGI:3575430
    See related
    Ensembl:ENSMUSG00000070531 AllianceGenome:MGI:3575430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WAP6b; Wfdc6
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 82.5) See more
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    Genomic context

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    Location:
    2 H3; 2 85.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164455431..164460133)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164613511..164618213)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene epididymal peptidase inhibitor Neighboring gene WAP four-disulfide core domain 8 Neighboring gene predicted gene, 25512 Neighboring gene predicted gene, 24473 Neighboring gene WAP four-disulfide core domain 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†. Andrade AD, et al. Biol Reprod, 2021 Jan 4. PMID 33034631
    2. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, et al. Biochem Biophys Res Commun, 2005 Jul 29. PMID 15950183, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 6B
    Names
    WAP four-disulfide core 6-like 1
    putative protease inhibitor WAP6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012725.3 → NP_001012743.2  WAP four-disulfide core domain protein 6B precursor

      See identical proteins and their annotated locations for NP_001012743.2

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS17046.2
      UniProtKB/Swiss-Prot
      B2RUM4, E9Q6A8, F6ULY1, Q5DQU6
      Related
      ENSMUSP00000091906.3, ENSMUST00000094346.3
      Conserved Domains (2) summary
      pfam00014
      Location:87 → 138
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:42 → 82
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164455431..164460133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499875.2 → XP_006499938.1  WAP four-disulfide core domain protein 6B isoform X1

      Conserved Domains (2) summary
      pfam00014
      Location:94 → 145
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:63 → 89
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6ULY1.1 GenPept UniProtKB/Swiss-Prot:F6ULY1

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