Mpo myeloperoxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpoprovided by MGI
Official Full Name: myeloperoxidaseprovided by MGI
Primary source: MGI:MGI:97137
See related: Ensembl:ENSMUSG00000009350 AllianceGenome:MGI:97137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4033
Summary: Enables peroxidase activity. Acts upstream of or within several processes, including hypochlorous acid biosynthetic process; removal of superoxide radicals; and response to fungus. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 72.3), liver E14 (RPKM 65.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 52.22 cM; 11 C

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (87684610..87695238)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87793784..87804412)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of neutrophil myeloperoxidase in the development and progression of high-altitude pulmonary edema.
Title: Role of neutrophil myeloperoxidase in the development and progression of high-altitude pulmonary edema.
Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer.
Title: Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer.
Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma.
Title: Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma.
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Title: Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice.
Title: Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice.
NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
Title: NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma.
Title: Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma.
Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms.
Title: Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms.
Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Title: Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.
Title: Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mpo (e-PCR), detects polymorphism
- UniSTS:143905

BB196773 (e-PCR)
- UniSTS:208724

D11Mit39 (e-PCR), detects polymorphism
- UniSTS:126587

RH144619 (e-PCR)
- UniSTS:233864

Mpo (e-PCR), detects polymorphism
- UniSTS:256398

X15378 (e-PCR)
- UniSTS:163511

Mpo (e-PCR), detects polymorphism
- UniSTS:507071

Mpo (e-PCR), detects polymorphism
- UniSTS:516594

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hypochlorous acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory burst involved in defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to yeast	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloperoxidase

NP_034954.2

EC 1.11.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.