Med23 mediator complex subunit 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med23provided by MGI
Official Full Name: mediator complex subunit 23provided by MGI
Primary source: MGI:MGI:1917458
See related: Ensembl:ENSMUSG00000019984 AllianceGenome:MGI:1917458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sno; Sur2; Crsp3; ESTM7; 130kDa; snouty; mKIAA1216; 3000002A17Rik
Summary: Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of T cell extravasation and positive regulation of gene expression. Part of mediator complex. Is expressed in several structures, including genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24745889..24789358)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24869986..24913529)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
Title: Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities.
Title: An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities.
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Title: Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Med23 Regulates Sox9 Expression during Craniofacial Development.
Title: Med23 Regulates Sox9 Expression during Craniofacial Development.
Study identifies Med23 as an essential transcriptional regulator that controls invariant natural killer T-cells differentiation and terminal maturation.
Title: Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.
Findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses.
Title: Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.
MED23 constitutes a molecular node in the regulatory network of anabolic bone formation and related diseases.
Title: Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development.
Med23 contributes to controlling T-cell activation at the transcriptional level and prevents the development of autoimmunity.
Title: The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity.
The hepatic Med23 deletion impaired the Mediator and RNAPII recruitment and attenuated the expression of FOXO1 target genes.
Title: Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity.
Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes.
Title: T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Chemically induced (ENU) (1) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of T cell extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of core mediator complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 23

Names: CRSP complex subunit 3; cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); mSur-2; protein sur-2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166416.2 → NP_001159888.2 mediator of RNA polymerase II transcription subunit 23 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC159502

Consensus CDS

CCDS48522.1

Related

ENSMUSP00000090316.8, ENSMUST00000092646.13
NM_027347.4 → NP_081623.4 mediator of RNA polymerase II transcription subunit 23 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC159502

Consensus CDS

CCDS35871.2

UniProtKB/Swiss-Prot

Q6ZPV7, Q80YQ2, Q8CEC3, Q8K587, Q9CXY8

Related

ENSMUSP00000020159.10, ENSMUST00000020159.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

24745889..24789358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155991.1 → XP_036011884.1 mediator of RNA polymerase II transcription subunit 23 isoform X1

UniProtKB/TrEMBL

F8WJB0

Conserved Domains (1) summary

pfam11573
Location:4 → 1278

Med23; Mediator complex subunit 23