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    Cdk12 cyclin dependent kinase 12 [ Mus musculus (house mouse) ]

    Gene ID: 69131, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cdk12provided by MGI
    Official Full Name
    cyclin dependent kinase 12provided by MGI
    Primary source
    MGI:MGI:1098802
    See related
    Ensembl:ENSMUSG00000003119 AllianceGenome:MGI:1098802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik
    Summary
    Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 61.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98093259..98171941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98202433..98281101)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E10712 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:98063825-98064126 Neighboring gene predicted gene, 38963 Neighboring gene STARR-positive B cell enhancer ABC_E7054 Neighboring gene microRNA 5119 Neighboring gene STARR-seq mESC enhancer starr_30664 Neighboring gene predicted gene, 31194 Neighboring gene predicted gene, 31317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway. Liu S, et al. Exp Cell Res, 2023 Jul 1. PMID 37100369
    2. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. Cheng L, et al. Cancer Res, 2022 Oct 4. PMID 35857807
    3. Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene. Wang B, et al. Mol Ther, 2022 Oct 5. PMID 35581939, Free PMC Article
    4. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Dubbury SJ, et al. Nature, 2018 Dec. PMID 30487607, Free PMC Article
    5. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Chen HR, et al. Exp Neurol, 2014 Nov. PMID 24999027

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/beta-catenin signaling pathway.
      Title: Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.
    2. The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
      Title: The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
    3. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
      Title: Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
    4. Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
      Title: Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
    5. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker
      Title: CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
    6. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.
      Title: Cdk12 is essential for embryonic development and the maintenance of genomic stability.
    7. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways
      Title: Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.
    8. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
      Title: Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141525

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin K-CDK12 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 12
    Names
    CDC2-related kinase 7
    CDC2-related kinase, arginine/serine-rich
    CDC2-related protein kinase 7
    cell division cycle 2-related protein kinase 7
    cell division protein kinase 12
    protein kinase for splicing component
    NP_001103096.1
    NP_001103098.1
    NP_081228.2
    XP_006534171.1
    XP_011247527.1
    XP_030102133.1
    XP_030102134.1
    XP_030102135.1
    XP_036012845.1
    XP_036012846.1
    XP_036012848.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109626.1 → NP_001103096.1  cyclin-dependent kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_001103096.1

      Status: VALIDATED

      Source sequence(s)
      AA066711, AK049376, AL591205, BC116645
      Consensus CDS
      CCDS48901.1
      UniProtKB/Swiss-Prot
      A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
      Related
      ENSMUSP00000103162.2, ENSMUST00000107538.2
      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. NM_001109628.1 → NP_001103098.1  cyclin-dependent kinase 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA066711, AK129237, AL591205, BC116645
      Consensus CDS
      CCDS48902.1
      UniProtKB/Swiss-Prot
      Q14AX6
      Related
      ENSMUSP00000103163.2, ENSMUST00000107539.8
      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    3. NM_026952.2 → NP_081228.2  cyclin-dependent kinase 12 isoform 3

      See identical proteins and their annotated locations for NP_081228.2

      Status: VALIDATED

      Source sequence(s)
      AA066711, AL591205, BC116645
      Consensus CDS
      CCDS25342.1
      UniProtKB/Swiss-Prot
      Q14AX6
      Related
      ENSMUSP00000003203.8, ENSMUST00000003203.14
      Conserved Domains (2) summary
      smart00220
      Location:723 → 1016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RNA

    1. NR_175406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591205

    2. NR_175407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591205

    3. NR_175408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591205

    4. NR_175409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591205

    5. NR_175478.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591205

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98093259..98171941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246273.1 → XP_030102133.1  cyclin-dependent kinase 12 isoform X1

      UniProtKB/Swiss-Prot
      A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. XM_006534108.4 → XP_006534171.1  cyclin-dependent kinase 12 isoform X2

      Conserved Domains (1) summary
      cd07864
      Location:714 → 1015
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    3. XM_036156952.1 → XP_036012845.1  cyclin-dependent kinase 12 isoform X4

      Conserved Domains (1) summary
      cd07864
      Location:714 → 1015
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    4. XM_011249225.4 → XP_011247527.1  cyclin-dependent kinase 12 isoform X10

      See identical proteins and their annotated locations for XP_011247527.1

      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    5. XM_036156955.1 → XP_036012848.1  cyclin-dependent kinase 12 isoform X9

      Conserved Domains (2) summary
      PRK08691
      Location:1136 → 1313
      PRK08691; DNA polymerase III subunits gamma and tau; Validated
      cd07864
      Location:715 → 997
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    6. XM_030246274.2 → XP_030102134.1  cyclin-dependent kinase 12 isoform X1

      UniProtKB/Swiss-Prot
      A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457
      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    7. XM_030246275.2 → XP_030102135.1  cyclin-dependent kinase 12 isoform X3

      Conserved Domains (1) summary
      cd07864
      Location:715 → 1016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    8. XM_036156953.1 → XP_036012846.1  cyclin-dependent kinase 12 isoform X5

      Conserved Domains (1) summary
      cd07864
      Location:715 → 997
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AX6.2 GenPept UniProtKB/Swiss-Prot:Q14AX6

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