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    Psmc3ip proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 19183, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmc3ipprovided by MGI
    Official Full Name
    proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1098610
    See related
    Ensembl:ENSMUSG00000019303 AllianceGenome:MGI:1098610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOP2; GT198; Tbpip
    Summary
    Predicted to enable several functions, including DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Predicted to be involved in meiosis I and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Is expressed in metanephros; submandibular gland primordium; telencephalon ventricular layer; tooth; and vibrissa. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 36.1), CNS E11.5 (RPKM 17.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 64.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100981238..100986261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101092141..101095435, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100943626-100943809 Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene Coenzyme A synthase Neighboring gene MAX-like protein X Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein. Moktan H, et al. J Biol Chem, 2014 May 23. PMID 24711446, Free PMC Article
    2. The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis. Petukhova GV, et al. Dev Cell, 2003 Dec. PMID 14667414
    3. Hop2 interacts with the transcription factor CEBPα and suppresses adipocyte differentiation. Lin T, et al. J Biol Chem, 2021 Nov. PMID 34600885, Free PMC Article
    4. Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation. Zhang Y, et al. J Bone Miner Res, 2019 Dec. PMID 31433867, Free PMC Article
    5. The dual role of HOP2 in mammalian meiotic homologous recombination. Pezza RJ, et al. Nucleic Acids Res, 2014 Feb. PMID 24304900, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hop2 interacts with the transcription factor CEBPalpha and suppresses adipocyte differentiation.
      Title: Hop2 interacts with the transcription factor CEBPα and suppresses adipocyte differentiation.
    2. Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation.
      Title: Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation.
    3. HOP2-MND1 enhances the interaction of RAD51 with nucleotide cofactors and modifies its DNA-binding specificity.
      Title: HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.
    4. Results show the role of a coiled-coil structural feature involved in HOP2 self-association.
      Title: Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein.
    5. Authors propose that HOP2 may act as a recombinase with specific functions in meiosis.
      Title: The dual role of HOP2 in mammalian meiotic homologous recombination.
    6. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
      Title: Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
    7. C-terminal basic region of TBPIP/HOP2 is required for efficient DNA binding and is also essential for its homologous pairing stimulation activity
      Title: Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing.
    8. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis
      Title: The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables recombinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic joint molecule formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA recombinase auxiliary factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homologous-pairing protein 2 homolog
    Names
    PSMC3-interacting protein
    TBP-1-interacting protein
    proteasome 26S ATPase subunit 3-interacting protein
    tat-binding protein 1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008949.3 → NP_032975.1  homologous-pairing protein 2 homolog

      See identical proteins and their annotated locations for NP_032975.1

      Status: VALIDATED

      Source sequence(s)
      AK133462, BF658859, BX255926
      Consensus CDS
      CCDS25448.1
      UniProtKB/Swiss-Prot
      O35047, Q3V035
      UniProtKB/TrEMBL
      C4PFH5
      Related
      ENSMUSP00000019447.9, ENSMUST00000019447.15
      Conserved Domains (1) summary
      pfam07106
      Location:16 → 179
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100981238..100986261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245675.2 → XP_030101535.1  homologous-pairing protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      C4PFH6
      Conserved Domains (1) summary
      pfam18517
      Location:45 → 100
      LZ3wCH; Leucine zipper with capping helix domain

    2. XM_006532524.4 → XP_006532587.1  homologous-pairing protein 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_006532587.1

      UniProtKB/TrEMBL
      C4PFH6
      Conserved Domains (1) summary
      pfam18517
      Location:45 → 100
      LZ3wCH; Leucine zipper with capping helix domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35047.1 GenPept UniProtKB/Swiss-Prot:O35047

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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