Arhgap24 Rho GTPase activating protein 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap24provided by MGI
Official Full Name: Rho GTPase activating protein 24provided by MGI
Primary source: MGI:MGI:1922647
See related: Ensembl:ENSMUSG00000057315 AllianceGenome:MGI:1922647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610025G21Rik
Summary: Enables GTPase activator activity. Acts upstream of or within several processes, including activation of GTPase activity; negative regulation of Rac protein signal transduction; and negative regulation of ruffle assembly. Located in focal adhesion. Is expressed in several structures, including axial skeleton; central nervous system; cranium; jaw; and metanephros. Orthologous to human ARHGAP24 (Rho GTPase activating protein 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 13.2), bladder adult (RPKM 1.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 49.53 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (102355043..103053743)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (102207198..102905035)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased levels of active Rac1 and Cdc42 were measured in Arhgap24 knockdown experiments, which influenced podocyte cell shape and membrane dynamics.
Title: Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B501 (e-PCR)
- UniSTS:130602

D5Mit64.2 (e-PCR), detects polymorphism
- UniSTS:130603

D1S3690 (e-PCR)
- UniSTS:474268

RH118293 (e-PCR)
- UniSTS:160946

D5Mit364 (e-PCR), detects polymorphism
- UniSTS:130517

RH134569 (e-PCR)
- UniSTS:217849

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ruffle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of epidermal cells	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 24

Names: rho-type GTPase-activating protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286468.1 → NP_001273397.1 rho GTPase-activating protein 24 isoform 2

See identical proteins and their annotated locations for NP_001273397.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AA221552, AK039617, AK080986, BB843608

Consensus CDS

CCDS19475.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Related

ENSMUSP00000108473.2, ENSMUST00000112852.8

Conserved Domains (3) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:567 → 630

Tropomyosin_1; Tropomyosin like

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
NM_001346585.1 → NP_001333514.1 rho GTPase-activating protein 24 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA221552, AC125252

Consensus CDS

CCDS84922.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

UniProtKB/TrEMBL

D3Z5T4

Related

ENSMUSP00000070048.5, ENSMUST00000070000.6
NM_029270.2 → NP_083546.2 rho GTPase-activating protein 24 isoform 1

See identical proteins and their annotated locations for NP_083546.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA221552, AK031879, AK080986, BC027070

Consensus CDS

CCDS19474.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

UniProtKB/TrEMBL

G3X9N1

Related

ENSMUSP00000092138.3, ENSMUST00000094559.9

Conserved Domains (3) summary

cd04390
Location:129 → 327

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:660 → 723

Tropomyosin_1; Tropomyosin like

cl17171
Location:20 → 129

PH-like; Pleckstrin homology-like domain
NM_146161.3 → NP_666273.1 rho GTPase-activating protein 24 isoform 2

See identical proteins and their annotated locations for NP_666273.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AA221552, AK052395, AK080986, BC027070

Consensus CDS

CCDS19475.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Related

ENSMUSP00000073028.6, ENSMUST00000073302.12

Conserved Domains (3) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:567 → 630

Tropomyosin_1; Tropomyosin like

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

102355043..103053743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534888.3 → XP_006534951.1 rho GTPase-activating protein 24 isoform X2

See identical proteins and their annotated locations for XP_006534951.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

UniProtKB/TrEMBL

G3X9N1

Conserved Domains (3) summary

cd04390
Location:129 → 327

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:660 → 723

Tropomyosin_1; Tropomyosin like

cl17171
Location:20 → 129

PH-like; Pleckstrin homology-like domain
XM_036165071.1 → XP_036020964.1 rho GTPase-activating protein 24 isoform X1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Conserved Domains (3) summary

COG1196
Location:705 → 791

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:186 → 384

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:20 → 186

PH-like; Pleckstrin homology-like domain
XM_006534887.4 → XP_006534950.1 rho GTPase-activating protein 24 isoform X2

See identical proteins and their annotated locations for XP_006534950.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

UniProtKB/TrEMBL

G3X9N1

Conserved Domains (3) summary

cd04390
Location:129 → 327

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:660 → 723

Tropomyosin_1; Tropomyosin like

cl17171
Location:20 → 129

PH-like; Pleckstrin homology-like domain
XM_036165070.1 → XP_036020963.1 rho GTPase-activating protein 24 isoform X1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Conserved Domains (3) summary

COG1196
Location:705 → 791

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:186 → 384

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:20 → 186

PH-like; Pleckstrin homology-like domain
XM_036165072.1 → XP_036020965.1 rho GTPase-activating protein 24 isoform X1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Conserved Domains (3) summary

COG1196
Location:705 → 791

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:186 → 384

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cl17171
Location:20 → 186

PH-like; Pleckstrin homology-like domain
XM_006534891.5 → XP_006534954.1 rho GTPase-activating protein 24 isoform X3

See identical proteins and their annotated locations for XP_006534954.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Related

ENSMUSP00000108474.2, ENSMUST00000112853.8

Conserved Domains (3) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:567 → 630

Tropomyosin_1; Tropomyosin like

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_011249434.3 → XP_011247736.1 rho GTPase-activating protein 24 isoform X3

See identical proteins and their annotated locations for XP_011247736.1

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Conserved Domains (3) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:567 → 630

Tropomyosin_1; Tropomyosin like

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_006534892.4 → XP_006534955.1 rho GTPase-activating protein 24 isoform X4

UniProtKB/Swiss-Prot

Q8C4V1, Q8CA50, Q8QZZ0

Conserved Domains (2) summary

cd04390
Location:5 → 203

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam12718
Location:536 → 599

Tropomyosin_1; Tropomyosin like