Gorasp2 golgi reassembly stacking protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gorasp2provided by MGI
Official Full Name: golgi reassembly stacking protein 2provided by MGI
Primary source: MGI:MGI:2135962
See related: Ensembl:ENSMUSG00000014959 AllianceGenome:MGI:2135962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p59; GRS2; GOLPH2; GRASP55; 0610011A07Rik; 2410043M02Rik; 5730520M13Rik; 9430094F20Rik
Summary: Predicted to be involved in several processes, including Golgi organization; establishment of protein localization to plasma membrane; and response to endoplasmic reticulum stress. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in Golgi medial cisterna; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 74.9), adrenal adult (RPKM 71.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 41.82 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (70491520..70522069)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (70661509..70691725)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of GORASPs in Golgi apparatus organization in vivo.
Title: The function of GORASPs in Golgi apparatus organization in vivo.
GRASP55 Is Dispensable for Normal Hematopoiesis but Necessary for Myc-Dependent Leukemic Growth.
Title: GRASP55 Is Dispensable for Normal Hematopoiesis but Necessary for Myc-Dependent Leukemic Growth.
Genetic inactivation of the Golgi-resident protein GRASP55 in mice reduces whole-body fat mass via impaired intestinal fat absorption and evokes resistance to high-fat diet induced body weight gain.
Title: Grasp55(-/-) mice display impaired fat absorption and resistance to high-fat diet-induced obesity.
PERK inhibition, on the other hand, controls caspase-1-mediated conversion of proIL-1beta to mIL-1beta. These findings reveal translation-independent functions of PERK and IRE1alpha: PERK controls the production of mIL-1beta, which is then followed by GRASP55 and IRE1alpha activity to keep mIL-1beta in a secretion-competent form.
Title: GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.
Our functional study of GOLPH2 helps advance the scientific understanding of the biological and pathogenic roles of this novel and intriguing molecule
Title: Golgi Phosphoprotein 2 Is a Novel Regulator of IL-12 Production and Macrophage Polarization.
GOLPH2 promotes the progression of pancreatic ductal adenocarcinoma.
Title: GOLPH2, a gene downstream of ras signaling, promotes the progression of pancreatic ductal adenocarcinoma.
Gorasp2-/- mice suffered from spermatogenesis defects. Golgi morphology of spermatocytes was disturbed in Gorasp2-/- mice. GRASP55 interacted via PDZ-mediated interactions with JAMs.
Title: Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.
GRASP55 responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b and IL-18
Title: Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in organelle organization	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi reassembly-stacking protein 2

Names: golgi reassembly-stacking protein of 55 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027352.4 → NP_081628.3 Golgi reassembly-stacking protein 2

See identical proteins and their annotated locations for NP_081628.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the protein-coding transcript.

Source sequence(s)

AK169382, BU707592

Consensus CDS

CCDS16109.1

UniProtKB/Swiss-Prot

Q3U9D2, Q8CCD0, Q91W68, Q99JX3

UniProtKB/TrEMBL

Q3TX06

Related

ENSMUSP00000028509.5, ENSMUST00000028509.11

Conserved Domains (2) summary

pfam04495
Location:69 → 205

GRASP55_65; GRASP55/65 PDZ-like domain

cl00117
Location:14 → 100

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RNA

NR_027343.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that disrupts the reading frame. This variant is not thought to be protein-coding.

Source sequence(s)

AK168928, AK169382, BU707592

Related

ENSMUST00000112201.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

70491520..70522069

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162559.1 → XP_036018452.1 Golgi reassembly-stacking protein 2 isoform X1

UniProtKB/TrEMBL

Q3TX06

Conserved Domains (2) summary

pfam04495
Location:69 → 205

GRASP55_65; GRASP55/65 PDZ-like domain

cl00117
Location:14 → 100

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...