Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc10a6provided by MGI
Official Full Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 6provided by MGI
Primary source: MGI:MGI:1923000
See related: Ensembl:ENSMUSG00000029321 AllianceGenome:MGI:1923000
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Soat; 8430417G17Rik
Summary: Predicted to enable bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-dependent organic anion transport. Predicted to act upstream of or within sodium ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in metanephros. Orthologous to human SLC10A6 (solute carrier family 10 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 9.0), subcutaneous fat pad adult (RPKM 3.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (103753583..103777152, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (103605711..103629403, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc10a6 role in the supply of steroids in the testis and consequently for spermatogenesis and fertility.
Title: Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

C78479 (e-PCR)
- UniSTS:159405

Slc10a6 (e-PCR), detects polymorphism
- UniSTS:545983

NoName (e-PCR)
- UniSTS:235238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-dependent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent organic anion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium-dependent organic anion transporter

Names: solute carrier family 10 member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029415.3 → NP_083691.1 sodium-dependent organic anion transporter

See identical proteins and their annotated locations for NP_083691.1

Status: VALIDATED

Source sequence(s)

AC161169

Consensus CDS

CCDS19477.1

UniProtKB/Swiss-Prot

B2RTH4, Q9CXB2

Related

ENSMUSP00000031263.2, ENSMUST00000031263.2

Conserved Domains (1) summary

TIGR00841
Location:32 → 312

bass; bile acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

103753583..103777152 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535278.4 → XP_006535341.1 sodium-dependent organic anion transporter isoform X1

Conserved Domains (1) summary

cl19217
Location:1 → 184

SBF; Sodium Bile acid symporter family