Slc10a4 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc10a4provided by MGI
Official Full Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 4provided by MGI
Primary source: MGI:MGI:3606480
See related: Ensembl:ENSMUSG00000029219 AllianceGenome:MGI:3606480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130304D01
Summary: Predicted to enable bile acid:sodium symporter activity. Involved in regulation of neurotransmitter loading into synaptic vesicle. Acts upstream of or within adult behavior and response to xenobiotic stimulus. Located in cholinergic synapse and serotonergic synapse. Is integral component of synaptic vesicle membrane. Is active in dopaminergic synapse. Is expressed in genitourinary system and nervous system. Orthologous to human SLC10A4 (solute carrier family 10 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 7.8), whole brain E14.5 (RPKM 7.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (73164247..73170298)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (73006904..73012955)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders?
Title: Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders?
In summary, SLC10A4 acts as a regulator of degranulation in vitro and of mast cell-related reactions in vivo.
Title: SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo.
Study indicates that loss of SLC10A4 protein results in neurotransmitter imbalance and cognitive impairment in null mice
Title: Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4.
SLC10A4 failed to show transport activity for a series of neurotransmitters and neuromodulators, indicating that SLC10A4 does not seem to represent a typical neurotransmitter transporter such as DAT, SERT, CHT1 or VMAT2
Title: Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes.
Results demonstrate that SLC10A4 is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo
Title: SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis.
Results suggest that VAAT modulates neuromuscular junction transmission efficiency and, as such, may represent a novel target for treatment of disorders affecting motor neurons
Title: A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction.
absence of the recently discovered synaptic vesicle protein Slc10a4 results in increased sensitivity to cholinergic stimulation
Title: The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Slc10a4 (e-PCR), detects polymorphism
- UniSTS:546988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter loading into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter loading into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in dopaminergic synapse	IC Inferred by Curator more info	PubMed
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in serotonergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in serotonergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: sodium/bile acid cotransporter 4

Names: Na(+)/bile acid cotransporter 4; solute carrier family 10 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.