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    Inhba inhibin beta-A [ Mus musculus (house mouse) ]

    Gene ID: 16323, updated on 20-Jul-2021

    Summary

    Official Symbol
    Inhbaprovided by MGI
    Official Full Name
    inhibin beta-Aprovided by MGI
    Primary source
    MGI:MGI:96570
    See related
    Ensembl:ENSMUSG00000041324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in ovary adult (RPKM 8.8), liver E18 (RPKM 1.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Inhba in Genome Data Viewer
    Location:
    13 A1; 13 5.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (16178841..16206194)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (16004256..16031609)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (16106308..16119044)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530046M15 gene Neighboring gene U1 small nuclear ribonucleoprotein 1C pseudogene Neighboring gene predicted gene, 31450 Neighboring gene predicted gene, 22628 Neighboring gene predicted gene 6562

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inhibin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type II activin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GABAergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eyelid development in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mesodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ovulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in progesterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striatal medium spiny neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of activin A complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inhibin A complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibin beta A chain
    Names
    activin A
    activin beta-A chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008380.2NP_032406.1  inhibin beta A chain preproprotein

      See identical proteins and their annotated locations for NP_032406.1

      Status: REVIEWED

      Source sequence(s)
      AC154742, AC161586, AK134991, BP759054
      Consensus CDS
      CCDS26251.1
      UniProtKB/Swiss-Prot
      Q04998
      UniProtKB/TrEMBL
      Q3UY39
      Related
      ENSMUSP00000047894.7, ENSMUST00000042603.14
      Conserved Domains (2) summary
      pfam00688
      Location:56291
      TGFb_propeptide; TGF-beta propeptide
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      16178841..16206194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244285.3XP_011242587.1  inhibin beta A chain isoform X1

      See identical proteins and their annotated locations for XP_011242587.1

      UniProtKB/Swiss-Prot
      Q04998
      UniProtKB/TrEMBL
      Q3UY39
      Related
      ENSMUSP00000132085.2, ENSMUST00000164993.2
      Conserved Domains (2) summary
      pfam00688
      Location:56291
      TGFb_propeptide; TGF-beta propeptide
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
    2. XM_006516559.4XP_006516622.1  inhibin beta A chain isoform X1

      See identical proteins and their annotated locations for XP_006516622.1

      UniProtKB/Swiss-Prot
      Q04998
      UniProtKB/TrEMBL
      Q3UY39
      Conserved Domains (2) summary
      pfam00688
      Location:56291
      TGFb_propeptide; TGF-beta propeptide
      cd19404
      Location:317424
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
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