Agtrap angiotensin II, type I receptor-associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agtrapprovided by MGI
Official Full Name: angiotensin II, type I receptor-associated proteinprovided by MGI
Primary source: MGI:MGI:1339977
See related: Ensembl:ENSMUSG00000029007 AllianceGenome:MGI:1339977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AT1R; Atrap; D4Wsu124e; 3300002E14Rik
Summary: Enables angiotensin type II receptor activity. Acts upstream of or within regulation of blood pressure. Located in cell cortex and plasma membrane. Is expressed in several structures, including genitourinary system; ileum; liver; lung; and spleen. Used to study acquired metabolic disease. Orthologous to human AGTRAP (angiotensin II receptor associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 26.3), kidney adult (RPKM 17.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 78.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148161518..148172521, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148077061..148088064, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap.
Title: miR-125a-5p/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap.
Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity.
Title: Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity.
Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies.
Title: Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies.
Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization.
Title: Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization.
Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization.
Title: Deficiency of the kidney tubular angiotensin II type1 receptor-associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization.
The Functional Interaction of EGFR with AT1R or TP in Primary Vascular Smooth Muscle Cells Triggers a Synergistic Regulation of Gene Expression.
Title: The Functional Interaction of EGFR with AT1R or TP in Primary Vascular Smooth Muscle Cells Triggers a Synergistic Regulation of Gene Expression.
Lay A TRAP for myeloid cell response in diabetic kidney disease.
Title: Lay A TRAP for myeloid cell response in diabetic kidney disease.
Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor.
Title: Myogenic Vasoconstriction Requires Canonical G(q/11) Signaling of the Angiotensin II Type 1 Receptor.
Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury.
Title: Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury.
The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.
Title: The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125553 (e-PCR)
- UniSTS:162367

NoName (e-PCR)
- UniSTS:235095

RH125727 (e-PCR)
- UniSTS:142493

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables angiotensin type II receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: type-1 angiotensin II receptor-associated protein

Names: AT1 receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301281.1 → NP_001288210.1 type-1 angiotensin II receptor-associated protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR that causes translation initiation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AL606929

Conserved Domains (1) summary

cl05741
Location:1 → 106

AGTRAP; Angiotensin II, type I receptor-associated protein (AGTRAP)
NM_009642.5 → NP_033772.2 type-1 angiotensin II receptor-associated protein isoform 1

See identical proteins and their annotated locations for NP_033772.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK152467, AL606929, CO040736

Consensus CDS

CCDS18930.1

UniProtKB/Swiss-Prot

B2KFL8, Q3U7X6, Q9D8Z8, Q9D940, Q9WVK0

Related

ENSMUSP00000030865.9, ENSMUST00000030865.9

Conserved Domains (1) summary

smart00805
Location:1 → 161

AGTRAP; Angiotensin II, type I receptor-associated protein